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Cardiovascular Disease and Use of Combined OralContraceptives


Authors: M. Novotná 1;  V. Unzeitig 2;  Novotnýt. 3
Authors‘ workplace: Gynekologicko porodnické oddělení, Nemocnice Milosrdných bratří, Brno, přednosta prim. MUDr. I. Huvar, CSc. 2 I. gynekologicko-porodnická klinika LF MU, Brno, přednosta prof. MUDr. P. Ventruba, DrSc. 3 Interní kardiologická klinika, LF MU, Brno, přednosta 1
Published in: Ceska Gynekol 2002; (3): 0

Overview

Objective:
To determine the association between myocardial infarction and cerebral stroke anduse of combined oral contraceptives.Design:Review of literature.Setting:Department of Obstetrics and Gynaecology,Hospital of Merciful Brothers,Brno,CzechRepublic. Methods:Identification of methodologically sound studies able to address the topic.Studies wereidentified by Medline database search.Results:Five the most recent and important studies were the main source of information (OxfordFamily Planning Association Contraception Study 1984,Royal College of General Practitioners ’Study 1994,WHO Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception 1996,1997,Transnational Study on Oral Contraceptives and the Health of Young Women 1997,Myocardial Infarction and Oral Contraceptives Study,1997).Generally there was no evidence ofa significantly increased risk of arterial wall disease in healthy non smoked users younger than35 years.No difference between second and third generation oral contraceptives on risk of arterial wall disease were found.In the most of cases of myocardial infarction or stroke one or morerisk factor were identified.Two of the most relevant risk factors are smoking and the absence ofblood pressure control.Conclusion:The risk of arterial cardiovascular system diseases seems not to be increased atno-risk users (healthy non-smoker younger than 35 years).

Key words:
combined oral contraceptives,myocardial infarction,cerebral stroke

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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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