Authors: V. Paseková; K. Veselá; G. Tauwinklová; J. Veselý Authors‘ workplace: REPROMEDA, Centrum reprodukční medicíny, s. r. o., Brno, odborný vedoucí MUDr. J. Veselý, CSc. Published in: Ceska Gynekol 2001; (6): 435-440 Category:
Objective: To investigate whether the presence of pathogenic microorganisms in genital tract ofwoman and/or man affects fertilization rate, development of embryo and nidation and whether italters the outcome of in vitro fertilization (IVF).Design: Retrospective comparative clinical study.Setting: Repromeda, Centre of reproductive medicine, Ltd., Viniční 235, 615 00 Brno.Methods: 382 cycles of IVF were evaluated during the period 8/1999 - 11/2000. Age, body massindex, number of collected oocytes, fertilization rate, quality and number of transferred embryos,un/known microbial flora, pregnancy rate and pregnancy outcome were evaluated in all women.Parameters of spermiogram and un/known microbial flora in semen were evaluated in all men.Couples were divided into four groups: A. known microbial flora in both (woman and man); B.known microbial flora in woman; C. known microbial flora in man; D. unknown microbial flora inboth.Results: The presence of pathogenic microorganisms in genital tract has no influence on fertilization, nor on development of embryo. Number of pregnancies per embryotransfer was higher in thegroups A, B, C vs. group D; the difference is statistically significant (29%, 24%, 29% vs. 18%, P
Key words: pathogenic microbial flora, sexually transmitted diseases, in vitro fertilization, implantation, embryo
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