Authors: Kukla; Hrubá; Tyrlík Authors‘ workplace: Výzkumný ústav zdraví dítěte v Brně, ředitel MUDr. Roman Nekvasil, CSc., Ústav preventivního lékařství MU v Brně, přednosta doc. MUDr. Zuzana Brázdová, CSc. Published in: Ceska Gynekol 2001; (1): 24-29 Category:
ELSPAC (European Longitudinal Study of Pregnancy and Childhood) includes women living inthe town Brno and the district Znojmo, who accepted the participation on the project in their18th - 20th week of pregnancy within the period November 1990 - February 1992.Objective: Wide and repeated anamnestic and clinical observations both of parents and childrenallowes to analyse damages of pregnancy, foetal and neonatal development and child health andtheir relations to environmental conditions.Design: Prospective study.Setting: Research Institute of Child Health, Cejl 91, Brno.Methods: In the group of 3251 ELSPAC women, their smoking habit and occupational history hasbeen obtained by self-completed questionnaire. Data were analyzed and their associations todifferent damages of pregnancy and foetal development were evaluated. Data about health statuswere collected by physicians who used the unified methods.Results: Prevalence of all types of damages was higher among smokers compared to non-smokers:the differences were significant for bleeding during 2nd trimester and suspect intrauterine growth retardation. On the other hand, the prevalence of congenital malformations was similaramong smokers and non-smokers.The women™ exposure to organic solvents has shown the associations to bleeding at the 1st trimes-ter, to placental abnormalities and to congenital malformations: the observed prevalence of mal-formations was more than twice higher than that expected (OR 2.11, p
Key words: organic solvents, smoking, malformations
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