Efficacy and Safety of Tiapride (Tiapridal® drops) in the Treatment ofAgitation in the ElderlyPostmarketing study

Czech version

Authors: E. Topinková
Authors‘ workplace: Geriatrická klinika 1. LF UK a VFN, Praha Subkatedra gerontologie a geriatrie IPVZ, Praha, přednostka kliniky a vedoucí subkatedry prof. MUDr. E. Topinková, CSc.
Published in: Čes. a slov. Psychiat., , 2002, No. 6, pp. 317-322.
Category:

Overview

The aim of the prospective open post-marketing study was to evaluate safety and efficacy oftiapride (Tiapridal® drops) in a large sample of geriatric patients with behavioural disturbancesparticularly with psychomotor restlessness, agitation and aggression.1029 community care and long-term nursing care in-patients aged 65 + with an acute (less than 48hours) onset of behavioural symptoms were enrolled in the study. The average age of the samplewas 81±7.5 years. Tiapride at a daily dosage of 300 mg reduced the intensity of behaviouralsymptoms already after 2 days of treatment. Percentage of symptom intensity reduction assessedby BARS scale (Brief Agitation Rating Scale) reached – 35% and – 47% respectively after one and 2weeks of treatment (p

Key words:
behavioural disturbances, elderly, pharmacotherapy, tiapride.

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Article was published in

Czech and Slovak Psychiatry

2002 Issue 6