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Weibullova rovnice a kinetika disoluce
: Z. Zatloukal
: Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
: Čes. slov. Farm., 2004; , 332-335
:
Přimodelování kinetiky disoluce se používají dvě variantyWeibullovy rovnice ve dvouparametrovémnebo tříparametrovém tvaru, přičemž odhady jejich parametrů nejsou zcela srovnatelné. V úvodníčásti jsou shrnuty čtyři varianty rovnice a je charakterizován jejich vztah ke granulometrickéRosin–Rammler–Sperlingově rovnici. Kinetika liberace pilokarpiniumchloridu z lyofilizovanýchlamel s odstupňovaným množstvím hydroxypropylmethylcelulosy je vyjádřena uvedenými rovnicemia jsou porovnány jejich parametry. V závěru je obecně diskutována použitelnost rovnic a jejichsprávná interpretace při modelování disoluce léčivých látek z lékových forem.
Klíčová slova:
Weibullova rovnice – kinetika disoluce – hydroxypropylmethylcelulosa –pilokarpiniumchlorid
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Pharmacy Clinical pharmacology
Article was published inCzech and Slovak Pharmacy
2004 Issue 6-
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