Authors: A. Kavalírová; M. Pospíšilová; R. Hamoudová Authors‘ workplace: Katedra analytické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové Published in: Čes. slov. Farm., 2004; , 328-331 Category:
Capillary izotachophoresis (ITP) with conductimetric detection was employed to determine pindolol(PI) in the pharmaceutical preparation Apo-pindol. The optimal operational electrolytic system wascomposed of 10 mM of potassium picolinate and 10 mM picolinic acid (leading electrolyte, LE;pH=5.1) and 10 mM of formic acid as the terminating electrolyte (TE). The time and currents modeof analysis were 50 µA (800 s), 10 µA. The total period of analysis was about 19 minutes. The methodis suitable for the determination of PI in Apo-pindol tablets, RSD=1.45 % (n=6). The method wasvalidated from the viewpoint of precision, accuracy, and linearity of the ITP method. The accuracyof the method was determined by an analysis of a sample with an added standard and the recoverywas 98,0 %.
Key words: pindolol – isotachophoresis – pharmaceutical preparation – validation
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