Study of the Strenght of Compacts of Mixed Dry Binders Consisting of Powdered Celluloseand Directly Compressible Lactose

Overview

The paper studied the strength of compacts of dry binders consisting of powdered cellulose anddirectly compressible lactose. The powdered cellulose employed was Arbocel A300, the directlycompressible lactose, Pharmatosa DCL 21. The first step of the evaluation comprised the tensilestrength of compacts and sensitivity of dry binders alone to an addition of magnesium stearate. Thesamemethod of evaluation was then used for mixed dry binders from Arbocel A300 and PharmatosaDCL 21 in ratios of 3:1, 1:1 and 1:3. The tested concentrations of magnesium stearate were 0.4 and0.8 %. Sensitivity of dry binders to an addition of the lubricant was evaluated by means of lubricantsensitivity ratio (LSR) values. The compacts with the highest strength and at the same time thelowest sensitivity to an addition of magnesium stearate were produced using a mixture of ArbocelA300 and Pharmatosa DCL 21 in a ratio of 1:3. The evaluation also included the commerciallyproduced mixed dry binder Cellactosa 80, in which higher sensitivity to an addition of stearate thanin a mixture of Arbocel A300 and Pharmatosa DCL 21 in a ratio of 1:3 was found.

Key words:
Arbocel A300 – Pharmatosa DCL 21 – Cellactosa 80 – tensile strength of tablets –magnesium stearate