Analysis of Tablets Containing the Antihistamine Loratadine: A Contribution to theIdentification of Impurities

Czech version

Authors: N. Issa; M. Mlynárová
Authors‘ workplace: Štátny ústav pre kontrolu liečiv, Bratislava
Published in: Čes. slov. Farm., 2004; , 192-196
Category:

Overview

Thin-layer chromatography on silica gel (Merck) was employed to examine potential impuritiespresent in loratadine-containing tablets. A method usable for testing of impurities was elaborated,which suitably supplements the determination of loratadine content using the spectrophotometricmethod in the UV region. The method was validated for selected pharmaceuticals.

Key words:
laratadine –⁠ thin-layer chromatography (TLC) –⁠ impurities –⁠ validation

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Article was published in

Czech and Slovak Pharmacy

2004 Issue 4