Authors: R. Opatřilová; P. Mokrý; J. Csöllei; M. Blešová Authors‘ workplace: Ústav chemických léčiv, Farmaceutická fakulta VFU, Brno Published in: Čes. slov. Farm., 2002; , 305-309 Category:
The paper is devoted to the synthesis and study of some physico-chemical properties of a group ofsubstances – potential antagonists of beta-adrenergic receptors. The substances are derivatives ofaryloxyaminopropanol, where the basic part consists of diphenylmethylpiperazine and the aromaticpart is modified with alkyl esters (methyl to butyl) of carbamic acid in positions 2-, 3-, 4-. Therepresentation of the elements was confirmed by elemental analysis. The substances were characterizedby melting point, IR and UV spectra. Their solubility and surface acitivity were determined.The purity of prepared substances was examined by means of TLC.
Key words: preparation – aryloxyaminopropanol – surface tension – TLC
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