Therapy of Hyperhomocysteinemia by Vitamin B12

Czech version

Authors: M. Krajčovičová-Kudláčková; P. Blažíček ¹; K. Šebeková; M. Valachovičová
Authors‘ workplace: Ústav preventívnej a klinickej medicíny, Bratislava 1 Nemocnica Ministerstva obrany, Bratislava
Published in: Čes. slov. Farm., 2002; , 310-312
Category:

Overview

Prevalence of mild hyperhomocysteinemia in vegetarians and vegans is a consequence of vitaminB12 deficiency. Clinical study of homocysteine reduction by vitamin B12 consisted of subjectivehealthy adults on alternative nutrition (n=9) with vitamin B12 deficiency and with mild hyperhomocysteinemia.Vitamin B12 treatment was implemented by 5 intramuscular cyanocobalamininjections of a total content of 2200 µg during two weeks. Homocysteine level was significantlyreduced (from 22 µmol/l to 11.7 µmol/l; individual reduction 29–55 %). Vitamin B12 concentrationin blood was significantly increased (from 152 pmol/l to 277 pmol/l; individual%of increase 63–150).The results show a high effect of vitamin B12 treatment in homocysteine value reduction of subjectson alternative nutrition.

Key words:
hyperhomocysteinemia – vegetarians – vegans – vitamin B12

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