Authors: A. Liptáková; O. Uličná 1; Z. Ďurčková; P. Božek 2; O. Vančová 1 Authors‘ workplace: Ústav lekárskej chémie, biochémie a klinickej biochémie LF UK, Bratislava, Farmakobiochemické laboratórium III. internej kliniky LF UK, Bratislava, Nemocnica s poliklinikou Ministerstva vnútra, Bratislava Published in: Čes. slov. Farm., 2001; , 193-196 Category:
The aim of this study was to monitor the effect of the administration of antihypertensive druglosartan on: (1) the antioxidant status of rats with experimental insulin-dependent diabetesmellitus; (2) oxidative damage which is represented by the production of compounds which can reactwith thiobarbituric acid (TBARP), and (3) some metabolic parameters. Losartan administration didnot significantly influence the concentration of glucose, cholesterol, triacylglycerol, and uric acid inthe plasma of control and diabetic animals. In the liver tissue, the concentration of triacylglycerolsdecreased after losartan administration, but the concentration of cholesterol did not change. Thepresent authors have found that losartan administration increased the levels of water solubileantioxidants in the plasma of diabetic rats, which can result in a decrease of the TBARP levels inthe plasma of diabetic rats.
Key words: antioxidant status - losartan - diabetes mellitus - oxidative stress
Don‘t have an account? Create new account
Enter the email address that you registered with. We will send you instructions on how to set a new password.
