Analytical Evaluation of the Substance BL 443 Pivalate
Authors:
Ž. Bezáková; M. Stankovičová; J. Csöllei
Authors‘ workplace:
iv Veterinárnej a farmaceutickej Univerzity, Brno
; Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava, Ústav chemických lieè
Published in:
Čes. slov. Farm., 2001; , 197-202
Category:
Overview
The paper presents the results of an analytical evaluation and a study of some physicochemicalproperties of a new potential drug of the prodrug type Πthe substance BL 443 pivalate with anassumed antidysrhythmic effect. The structure of the substance has been confirmed by elementalanalysis, IR and UV spectroscopy. The following parameters were determined: melting point,solubility, dissociation constant, experimental partition coefficient in four different systems, andsurface activity. The chromatographic behaviour of the drug on a thin layer (adsorption andpartition chromatography) was also investigated. Acidimetric titration in non-aqueous medium andspectrophotometry in the ultraviolet region of the spectrum at the wavelength of the secondabsorption maximum of the drug was employed to determine the content of the drug in puresubstance.
Key words:
prodrug - BL 443 pivalate: butylester of [(2-pivaloyloxy-3-isopropylamino)--propoxy]phenylcarbamic acid - analytical profile - physicochemical properties
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2001 Issue 4
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