Advances in the Development of New Antituberculotics from the Group of Ortho--Condensed Heterocyclic CompoundsPart 1. Compounds Containing One Heteroatom in the Six-Membered Ring

Overview

Tuberculosis and other mycobacterial diseases are considered to be one of the most importantproblems of contemporary health service. Since 1985 and particularly in the 1990s and at presentthe search for new structures of antimycobacterial agents have ranked among the foremost areasof chemotherapeutic research. The present review paper is already the 16 th communication ina group of review papers about the development of new antituberculotics in recent 15 years. Theliterature search is based on the journal Chemical Abstracts, Current Awareness in Biomedicine,part Mycobacteria, and original papers. Current Awareness in Biomedicine is, however, a veryimperfect literature search source, recording only a fraction of communications. Though none of theortho-condensed heterocyclic compounds has been introduced into practice, the in vitro evaluatedactivities of some of them equalled those of routine antituberculotics. Polycyclic systems make it possible to widely model the structures, and therefore the present review paper can inspire a searchfor new structures of antimycobacterial agents.

Key words:
tuberculostatics - heterocycles - mycobacteria