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IN VITRO IN VITRO ÚČINOK CHINOLÓNOV NAHYDROFOBICITU ACINETOBACTER ACINETOBACTERBAUMANNII BAUMANNII
: A. Hoštacká
: Ústav preventívnej a klinickej medicíny, Bratislava
: Čes. slov. Farm., 1999; , 272-275
:
Testoval sa vplyv subinhibičných koncentrácií (sub-MICs) (1/4, 1/8, 1/16 a 1/32 MICs) štyrochchinolónových antibiotík na povrchovú hydrofobicitu dvoch kmeňov Acinetobacter baumannii (R1a R2). Hydrofobicita sa hodnotila testom adherencie baktérií na xylén a ich agregáciou v roztokochsíranu amónneho. Norfloxacín v koncentráciách 1/4 a 1/8 MIC znížil hydrofobicitu kmeňa R1a kmeňa R2 v koncentrácii 1/16 MIC. Ciprofloxacín bol účinný pre obidva kmene najmä v koncen-trácii 1/4 MICs. Enoxacín (1/8 MIC) významnejšie redukoval hydrofóbne vlastnosti len kmeňa R2.Ostatné koncentrácie vyššie uvedených antibiotík ako aj všetky testované koncentrácie pefloxacínuprakticky neovplyvnili povrchovú bakteriálnu hydrofobicitu.
Klíčová slova:
chinolóny – subinhibičné koncentrácie – Acinetobacter baumannii – povrchováhydrofobicita
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Pharmacy Clinical pharmacology
Article was published inCzech and Slovak Pharmacy
1999 Issue 6-
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