Authors: D. Sládková; I. Csiba 1 Authors‘ workplace: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava 1 Katedra chemickej teórie liečiv Farmaceutickej fakulty Univerzity Komenského, Bratislava Published in: Čes. slov. Farm., 1999; , 87-90 Category:
The paper describes the preparation of a series of six new organic ammonium salts of amphiphiliccharacter, derived from amine alcohol, of the general structure:CH3(CH2)9CH(OH)CH2N + (CH3)2R Br -R = C6 – C12A part of the synthesis of the above-mentioned compounds is also the preparation of 1-bromo-2-do-decanol. The aggregation properties of these compounds in aqueous solution, expressed by the valuesof the critical concentration of micelle formation (Table 2), and antimicrobial activity, expressed bythe minimum inhibitory concentration (Table 3), in dependence on the step-by-step lengthening ofthe alkyl chain while preserving the principal structure (2-hydroxydodecyl and methyl bound to thequaternary nitrogen) were examined.
Key words: ammonium salts – synthesis – aggregative properties – antimicrobial activity –N-alkyl-N-(2-hydroxydodecyl)-N,N-dimethylammonium bromides
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