Authors: Z. Zatloukal Authors‘ workplace: Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové Published in: Čes. slov. Farm., 1999; , 72-74 Category:
The paper examines the vacillation of the density of the foil lyophilised from hydrogel containing40 g/l of hydroxypropylmethylcellulose (HPMC 4000). Lamellae of a diameter of 0.55 cm were formedto estimate the density of cm 2 of xerogel. In comparison with traditional regressive methods, theuse of a two-dimensional correlogram is recommended. The most important finding is the achieve-ment of random vacillation of density in a distance of ca 2 cm in connection with stamping lamellaefrom the lyophilised foil. The findings make it possible to optimise the procedure of pouring hydrogelfor lyophilisation with a subsequent decrease in density vacillation of lyophilised ophthalmiclamellae.
Key words: lyophilisation – hydroxypropylmethylcellulose – xerogel – density – correlogram
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