A Study of Labeling Conditions of Derivatives of (2RS, 4R)-1,3-Carboxylic Acid with Technetium-99m
Authors:
A. Bumbálová; E. Havránek; J. Ja’afreh; V. Kettmann; J. Světlík; O. Štroffeková
Authors‘ workplace:
Katedra farmaceutickej analýzy a nukleárnej farmácie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in:
Čes. slov. Farm., 1999; , 21-26
Category:
Overview
The preparation of 99m Tc-complexes with twenty derivatives of (2RS,4R)-1,3-thiazolidin-4-carboxy- lic acid over a broad pH range (1.5–8.9) is described fora potential use in radiodiagnostic medicine. The labelling efficiency was checked by paperand thin layer chromatography and for all well-soluble compounds is higher than 90 %.Paper electrophoresis and gel chromatography indicated the presence of two types ofcomplexes differing in charge and molecular mass. The structure of both types of the 99mTc-complexes is also discussed. The organ distribution and its time dependence weredetermined in mice after i.v. application.
Key words:
radiodiagnostics – 99m Tc-complexes – derivatives ofthiazolidin-4-carboxylic acid
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
1999 Issue 1
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