Targeting and Controlled Release of Drugs Using Magnetoliposomes

Overview

The present paper deals with a stable drug delivery system which allows to concentrate the drug in a desired site and its programmable release. For these purposes the present authors have suggested to use magnetoliposomes (liposomes with enwrapped magnetite particles in their bilayers) which are magnetosensitive and may be maneuvered to the given site in the organism. Due to the magnetite particles, which are strong microwave absorbers, magnetoliposomes can be heated to higher temperatures which may subsequently lead to a leakage of encapsulated drug. Influence of static magnetic field on liposomes in the blood-stream was analyzed theoretically. Fluorescence spectro- photometry was used to determine the relationship between doses of microwave radiation and the extent of drug release.

Key words:
controlled drug delivery – magnetoliposomes – microwave radiation – magnetic field