Disturbances of the Plasma Coagulation Defects in Retinal Venous Occlusions
Authors:
M. Rehák 1,2; V. Krčová 3; E. Fric 1; L. Slavík 3; B. Bábková 1; Z. Prachařová 1; K. Langová 4; J. Řehák 1
Authors‘ workplace:
Oční klinika FN a UP, Olomouc, přednosta doc. MUDr. J. Řehák, CSc.
1; Klinik und Poliklinik für Augenheilkunde, Leipzig, přednosta prof. Dr. med. P. Wiedemann
2; Hemato-onkologická klinika FN a UP, Olomouc, přednosta prof. MUDr. K. Indrák, DrSc.
3; Ústav lékařské biofyziky UP, Olomouc, přednosta prof. Ing. J. Hálek, CSc.
4
Published in:
Čes. a slov. Oftal., 64, 2008, No. 3, p. 108-111
Overview
Occlusions of retinal veins (central and branch) represent multifactorialy-conditioned disease involving presumably older patients, in whom the changes of retinal vessels caused by hypertension and atherosclerosis present the most important pathophysiological factors for development of this disease. In last years, the intensive scientific research is focused to the explanation of the role of the defects of the coagulations cascade. Especially in younger patients, the most often mentioned defect of the coagulations cascade is called as APC-resistance. Up to 95 % of all patients with APC-resistance are carriers of so called Leiden mutation.
The aim of our study
was to establish the prevalence of the ACP-resistance in 92 patients with central or branch occlusion of the retinal vein verified by means of angiography treated at the Department of Ophthalmology, Faculty Hospital, Olomouc, Czech Republic, EU, during the period 1999–2005.The control group consisted of 40 patients without any vascular, eye-related disease.
In the group of patients with occlusion of the retinal vein, the prevalence of the APC-resistance was 10.9 % and in the control group 5 %. In the group of patients 55 years old and younger the prevalence of the ACP-resistance was 14.3 %, in patients older than 55 years it was 5.6 %. According to the relatively small groups of patients, the established difference did not reach the level of statistical evidence. Results of our study confirmed the conclusions of previously published papers that the prevalence of the APC-resistance is not significantly higher in patients with retinal vein occlusion according to the prevalence in controls.
Key words:
retinal venous occlusion, trombophillia, ACP-resistance, Leiden-mutation
Sources
1. Albisinni, R.: Retinal vein occlusion and inherited conditions predisposing to thrombophilia. Thromb. Haemost., 80, 1998: 702-703.
2. Aras, S. Yilmaz, G., Alpas, I. Et al.: Retinal vein occlusion and factor V Leiden and prothrombin 20210 G:A mutations. Eur. J. Ophthalmol., 11, 2001: 351-355.
3. Arsene, S., Delahousse, B., Regina, S. et al.: Increased prevalence of factor V Leiden in patients with retinal vein occlusion and under 60 years of age. Thromb. Haemost., 94, 2005: 101-106.
4. Bertina, R.M., Koelemann, B.P.C., Koster, T. et al.: Mutation in blood coagulations factor V associated with resistance to activated protein C. Nature, 369, 1994: 64-67.
5. Bombeli, T., Basic, A., Fehr, J.: Prevalence of hereditary thrombophilia in patients with thrombosis in different venous systems. Am. J. Hematol., 70, 2002: 126-132.
6. Cahill, M.T., Stinnett, S.S., Fekrat, S.: Meta-analysis of plasma homocysteine, serum folate, serum vitamin B(12), and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive disease. Am. J. Ophthalmol., 136, 2003: 1136-1150.
7. Cruciani, F., Moramarco, A., Curto, T. et al.: MTHFR C677T mutation, factor II G20210A mutation and factor V Leiden as risks factor for youth retinal vein occlusion. Clin. Ter., 154, 2003: 299-303
8. Dahlbäck, B., Carlsson, M., Svensson, P.J.: Familiar thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: predilection of a cofactor to activated protein C. Proc. Natl. Acad. Sci. USA., 90, 1993: 1004-1008.
9. Demirci, F.Y.K., Güney, D.B., Akarcay, K. et al.: Prevalence of factor V Leiden in patients with retinal vein occlusion. Acta Ophthalmol. Scand., 77, 1999: 631-633.
10. Dithmar, S., Hansen, L.L., Holz, F.G.: Venöse retinale Verschlüsse. Ophthalmologe, 100, 2003: 561-578.
11. Faude, S., Faude, F., Siegemund, A. et al. : Activated protein C resistance in patients with central retinal vein occlusion in comparison to patients with a history of deep-vein thrombosis and a healthy control group. Ophthalmologe, 96, 1999: 594-599.
12. Gori, A.M., Marcucci, R., Fatini, C. et al. : Impaired fibrinolysis in retinal vein occlusion: a role for genetic determinants of PAI-1 levels. Thromb. Haemost. 92, 2004: 54-60.
13. Gottlieb, J.L., Blice, J.P., Mestichelli, B. et al.: Activated protein C resistance, factor V Leiden, and central retinal vein occlusion in young adults. Arch. Ophthalmol., 116, 1998: 577-579.
14. Greiner, K., Hafner, G., Dick, B. et al.: Retinal vascular occlusion and deficiencies in the protein C pathway. Am. J. Ophthalmol., 128, 1999: 69-74.
15. Hansen, L., Kristensen, H.L., Bek, T. et al.: Markers of thrombophilia in retinal vein thrombosis. Acta Ophthalmol. Scand., 78, 2000: 523-526.
16. Chak, M., Wallace, G.R., Graham, E.M. et al: Thrombophilia: genetic polymorphisms and their association with retinal vascular occlusive disease. Br. J. Ophthalmol., 85, 2001: 883-886.
17. Janssen, M.C., de Heijer, M., Cruysberg, J.R.M. et al.: Retinal vein occlusion: a form of venous thrombosis or a complication of atherosclerosis? Thromb. Haemost., 93, 2005: 1021-1026.
18. Kováčová, M., Pochop, P., Hochová, I. et al.: Přínos hematologického vyšetření u pacientů s venózní retinální okluzí. Čes. a slov. Oftal., 63, 2007: 193-198.
19. Kuhli, C., Hattenbach, L.O., Scharrer, I. et al.: High prevalence of resistance to APC in young patients with retinal vein occlusion. Graefe’s Arch. Clin. Exp. Ophthalmol., 240, 2002: 163-168.
20. Larsson, J., Hillarp, A., Olafsdottir, E. et al.: Activated protein C resistance and anticoagulant proteins in young adults with central retinal vein occlusion. Acta Ophthalmol. Scand., 77, 1999: 634-637.
21. Larsson, J., Olafsdottir, E., Bauer, B.: Activated protein C resistance in young adults with central retinal vein occlusion. Br. J. Ophthalmol., 80, 1996: 200-202.
22. Larsson, J., Sellman, A., Bauer, B.: Activated protein C resistance in patients with central retinal vein occlusion. Br. J. Ophthalmol., 81, 1997: 832-834.
23. Linna, T., Ylikorkala, A., Kontula, K. et al.: Prevalence of factor V Leiden in young adults with retinal vein occlusion. Thromb. Haemost., 77, 1997: 214-216.
24. Marcucci, R., Bertini, L., Giusti, B. et al.: Thrombophilic risk factors in patients with central retinal vein occlusion. Thromb. Haemost., 86, 2001: 772-776
25. Marcucci, R., Giusti, B., Betti, I. et al.: Genetic determinants of fasting and post-methionine hyperhomocysteinemia in patients with retinal vein occlusion. Thromb. Res., 110, 2003: 7-12.
26. Salomon, O., Moisseiev, J., Rosenberg, N. et al.: Analysis of genetic polymorphisms related to thrombosis and other risk factors in patients with retinal vein occlusion. Blood Coagul. Fibrinolysis, 9, 1998: 617-622.
27. Svensson, P.J., Zoller, B., Dahlback, B.: Evaluation of original and modified APC-resistance tests in unselected outpatients with clinically suspected thrombosis and in healthy controls. Thromb. Haemost., 77, 1997: 332-335.
28. Tekeli, O., Gürsel, E., Buyurgan, H.: Protein C, protein S and antithrombin III deficiencies in retinal vein occlusion. Acta Ophthalmol. Scand., 77, 1999: 628-630.
29. The Eye Disease Case-Control Study Group: Risk factors for central retinal vein occlusion. Arch. Ophthalmol., 114, 1996: 545-554.
30. Trossaert, M., Conard, J., Horellou, M.H. et al.: The modified APC resistance test in the presence of factor V deficient plasma can be used in patients without oral anticoagulant. Thromb. Haemost., 75, 1996: 521-522.
31. Weger, M., Renner, W., Steinbrugger, I. et al.: Role of thrombophilic gene polymorphisms in branch retinal vein occlusion. Ophthalmology, 112, 2005: 1910-1915.
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OphthalmologyArticle was published in
Czech and Slovak Ophthalmology
2008 Issue 3
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