Ofatumumab – a new high-efficacy treatment for relapsing forms of multiple sclerosis

Authors: M. Vališ;  S. Halúsková
Authors‘ workplace: Neurologická klinika LF UK a FN Hradec Králové
Published in: Cesk Slov Neurol N 2021; 84(5): 436-440
Category: Review Article
doi: 10.48095/cccsnn2021436


There has been tremendous progress in the treatment of MS over recent years. The concept of early treatment to achieve better outcomes in MS has clearly emerged, fully supported by long-term data. The efficacy of anti-CD20 monoclonal antibodies in the treatment of MS has been confirmed in clinical trials. Ofatumumab is a fully-humanized anti-CD20 monoclonal antibody approved for the treatment of adult patients with relapsing-remitting MS. Ofatumumab showed high efficacy and a favorable safety profile in phase III clinical trials, offering the first B-cell therapy that can be subcutaneously self-administered at home.


Multiple sclerosis – Monoclonal antibodies – treatment – ofatumumab


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