Authors: M. Žurková 1; P. Otruba 2; V. Lošťáková 1; Z. Tudos 3; V. Kolek 1; E. Kriegová 4 Authors‘ workplace: Klinika plicních nemocí a tuberkulózy LF UP a FN Olomouc 1; Neurologická klinika LF UP a FN Olomouc 2; Radiologická klinika LF UP a FN Olomouc 3; Ústav imunologie, LF UP v Olomouci 4 Published in: Cesk Slov Neurol N 2016; 79/112(2): 225-230 Category: Case Report doi: https://doi.org/10.14735/amcsnn2016225
Grantová podpora: IGA MZ ČR NT11117.
Sarcoidosis is a multisystem granulomatous disease of unknown origin that rarely affects the nervous system. Granulomatous process may affect all structures of the central and peripheral nervous system. Neurosarcoidosis is associated with bad prognosis and the treatment should be started at early stages of the disease. We present a case of a middle-aged man with sarcoidosis of the peripheral lung lymph nodes and lung parenchyma. After 10 years of follow-up, the disease progressed with cardiac and neurological involvement. The peripheral nervous system was affected with peripheral neuropathy associated with sarcoidosis; other reasons for peripheral neuropathy were excluded. Treatment with corticosteroids led to improvements in neurological symptoms. At present, the patient is on a maintenance dose of corticosteroids, shows low activity of lung disease and neurological findings have been stable throughout the follow-up period. A brief literature review of the latest diagnostic and treatment options in patients with neurosarcoidosis is presented, including the first experience with novel biological treatments of this rare, very serious disease.
Key words: sarcoidosis – neurosarcoidosis – involvement of central nervous system – peripheral neuropathy The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
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