Autonomic Dysfunction and its Diagnostic Tools in Multiple Sclerosis


Authors: I. Šrotová;  E. Vlčková;  J. Bednařík
Authors‘ workplace: Neurologická klinika LF MU a FN Brno ;  CEITEC – Středoevropský technologický institut, MU, Brno
Published in: Cesk Slov Neurol N 2016; 79/112(2): 188-198
Category: Review Article

Tato publikace vznikla na Masarykově univerzitě v rámci projektu „Diagnostika a patofyziologie neuropatické bolesti“ číslo MUNI/A/1072/2015 podpořeného z prostředků účelové podpory na specifický vysokoškolský výzkum, kterou poskytlo MŠMT v roce 2016, grantovým projektem Interní Grantové Agentury (IGA MZ ČR NT 13523-4), projektem MZ ČR –  RVO (FNBr, 65269705) a interními zdroji CEITEC MUNI.

Overview

Autonomic nervous system dysfunction (AD) represents a frequent clinical presentation of multiple sclerosis (MS). According to published studies, the incidence of AD in MS patients ranges between 16 and 80% and gradually increases with the length of the demyelinating disease and with the progression of disability. However, AD can occur in any phase of MS and can even represent its first symptom in some patients. Autonomic dysfunction has a significant negative impact on the quality of life in MS patients and contributes to overall disability. Even so, autonomic nervous system dysfunction is frequently underdiagnosed in patients with multiple sclerosis. Cardiovascular and urogenital dysfunction are the most frequent types of AD in MS patients with the highest impact on their clinical status and the quality of life. Less frequently, gastrointestinal, sudomotor or pupilomotor dysfunction can be found. Autonomic (in particular cardiovascular) dysfunction in multiple sclerosis is closely related to fatigue, another frequent clinical symptom in MS patients. The aim of this paper is to sum up the spectrum of symptoms of autonomic dysfunction in multiple sclerosis and its diagnostic tools.

Key words:
multiple sclerosis – autonomic nervous system diseases – orthostatic intolerance –urinary incontinence – urinary retention –sexual dysfunction – gastrointestinal dysfunction – sweating

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.


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