Addenbrooke’s Cognitive Examination –  Approximate Normal Values for the Czech Population


Authors: D. Beránková 1–3;  P. Krulová 1,4;  M. Mračková 2,5;  I. Eliášová 2,5;  M. Košťálová 2,6;  E. Janoušová 7;  I. Stehnová 5;  M. Bar 1;  P. Ressner 1;  P. Nilius 1;  M. Tomagová 4,8;  I. Rektorová 2,5
Authors‘ workplace: Centrum pro kognitivní poruchy, Neurologická klinika LF OU a FN Ostrava 1;  Výzkumná skupina Aplikované neurovědy, CEITEC – Středoevropský technologický institut MU, Brno 2;  Katedra rehabilitace, LF OU v Ostravě 3;  Ústav ošetřovatelství a porodní asistence, LF OU v Ostravě 4;  Neurologická klinika LF MU a FN u sv. Anny v Brně 5;  Neurologická klinika LF MU a FN Brno 6;  Institut biostatistiky a analýz, LF MU, Brno 7;  Ústav ošetrovateľstva, JLF UK v Bratislave 8
Published in: Cesk Slov Neurol N 2015; 78/111(3): 300-305
Category: Original Paper

Overview

Aim:
The aim of this study was to provide benchmark normal values for Addenbrooke’s cognitive examination (ACE-R) and its domains for the Czech population.

Methods:
The study included 143 healthy subjects (89 women and 54 men) aged 55–89 years, without brain injury, neurodegenerative disease, severe hearing or visual impairment and without a psychiatric disease, with MMSE above 27 points. Participants were interviewed in detail to ascertain any previous brain injury history and to determine the level of self-sufficiency in daily living activities. Individuals with a history of brain injury or impaired self-sufficiency were excluded from the study. ACE-R values and values for its domains in men and women were compared with Mann-Whitney test and values for the four age and education groups were compared using the Kruskal-Wallis test. P-values were corrected for multiple testing using Bonferroni correction.

Results:
Cut-off scores were set at 2nd and 7th percentile. Negative correlation with age (p < 0.001, r = –0.43) and positive correlation with education (p < 0.001, r = 0.41) were statistically significant for the overall test performance and also for the performance in individual cognitive domains except for the Attention and orientation domain. The effect of sex was not statistically significant. The cut-off score for the total score in Addenbrooke’s cognitive examination for all subjects aged 55–89 years is 74 points at the 2nd percentile and 79 points at the 7th percentile.

Conclusion:
The study suggests cut-off scores for the Czech population of ACE-R and provides the basis for the development of Czech norms for this test.

Key words:
Addenbrooke’s cognitive examination – normal values – cognitive deficit

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for biomedical papers.


Sources

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Paediatric neurology Neurosurgery Neurology

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