Myastenia with Positive Anti-MuSk-positive Antibodies in a Young Man: A Case Report


Authors: E. Ehler;  J. Latta
Authors‘ workplace: Neurologické oddělení, Krajská nemocnice Pardubice
Published in: Cesk Slov Neurol N 2008; 71/104(1): 101-104
Category: Case Report

Overview

Transient diplopia, dysarthria, dysphagia and dysphonia occured in a 21-year muscular man after a mild viral infection. Repetitive stimulation with mild decrement, non-improvement after pyridostigmin and absence of anti-ACHR antibodies gave evidence against neuromuscular transmission disorder. On the contrary signal hyperintensities on brain MRI created the basis for a long follow-up in a neurological outpatient department under the diagnosis brainstem symptomatology probably inflammatory origin. During the following years many attacs of dysarthria, nasolalia and dysphonia occured with only one and last  attack of dyspnea. Because of these complaints the patient was newly recommended to neurological department. We made a new evaluation of complaints and clinical finding, EMG studies and at last  blood samples for anti-MuSK antibodies were taken. Clinical findings and auxilliary investigations were typical for myasthenie with anti-MuSK antibodies. Clinical findings, comparison with anti-ACHR positive myasthenia, EMG findings and pharmacotherapy are objects of discussion.

Key words:
myasthenia – muscle specific kinase – anti-MuSK antibodies – repetitive stimulation – SF-EMG


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Labels
Paediatric neurology Neurosurgery Neurology

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Czech and Slovak Neurology and Neurosurgery

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2008 Issue 1

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