Authors: A. Kvasnička 1,2; Š. Kouřil 2; R. Brumarová 2; B. Piskláková 1,2; L. Štefaničková 1,2; D. Friedecký 1,2,* Authors‘ workplace: Lékařská fakulta, Univerzita Palackého v Olomouci, Olomouc, Česká republika 1; Oddělení klinické biochemie, Fakultní nemocnice Olomouc, Olomouc, Česká republika 2 Published in: Klin. Biochem. Metab., 31, 2023, No. 2, p. 32-36 doi: https://doi.org/10.61568/kbm.2023.009
The determination of lipid levels is a routine service provided by clinical biochemistry laboratories. It commonly includes several parameters such as triacylglycerols, cholesterol and lipoprotein particles. However, with the development of mass spectrometry, a separate field of lipidomics has emerged, which allows the comprehensive description and quantification of a lipidome containing hundreds of individual molecules. A promising direction for the use of lipidomics in routine laboratory diagnostics has emerged in recent years in the field of cardiovascular disease. Ratios of plasma levels of selected ceramides and phosphatidylcholines are combined to evaluate CERT1, CERT2 and other scores to predict events and death in patients with cardiovascular disease. This review article will elaborate on the above issues and discuss the potential of lipidomics in routine laboratory diagnostics.
Metabolism – cardiovascular disease – lipidomics – predictive markers
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