Prevalence of Thrombophilia in Patients with Severe Ovarian Hyperstimulation Syndrome

Czech version

Authors: Š. Machač ¹; M. Procházka ²; M. Lubušký ²
Authors‘ workplace: Klinika pro léčbu neplodnosti Unica, Brno, přednosta prof. MUDr. Z. Malý, CSc. ¹; Gynekologicko-porodnická klinika LF UP a FN, Olomouc, přednosta prof. MUDr. M. Kudela, CSc. ²
Published in: Ceska Gynekol 2005; 70(4): 254-257
Category: Original Article

Overview

Objective:
To determine the prevalence of markers of thrombophilia in patients with severe form of ovarian hyperstimulation syndrome

Design:
Retrospective case –⁠ control study

Setting:
Unica, Institute for Reproductive Medicine, Brno

Methods:
Blood samples to test for markers of thrombophilia were obtained from 30 patients who were hospitalised for severe OHSS. Results were compared with two control groups.

Results:
None of the patients with severe OHSS had antithrombin, protein C or protein S deficiencies. We also did not observe increased prothrombin level. Six patients had factor V Leiden mutation (heterozygotes) which is statistically significant compared to control group (p = 0.01, OR 4.65) and 12 patients had mutation of MTHFR 677 (heterozygotes). None had prothrombin G20210A mutation.

Conclusion:
We found a statistically significant increase in the prevalence of factor V Leiden mutation (heterozygot) in Czech infertile women with severe OHSS. These findings suggest the increased risk of development of OHSS in these patients.

Key words:
ovarian hyperstimulation syndrome, thrombophilia, factor V Leiden mutation