Effect of Surgical Treatment of Atrial Fibrillation on the Attainment and Maintenance of Sinus Rhythm in Patients Undergoing Concomitant Cardiac Surgery –⁠ Short-term Results

Overview

Background.
Atrial fibrillation is the most frequent sustained arrhythmia. It is associated with higher morbidity and mortality of patients. Cryoablation was introduced to the current practise in cardiac surgery as a non –⁠ pharmacological method of therapy of atrial fibrillation. The aim of the study was to assess the effect of surgical ablation of atrial fibrillation on the attainment and maintenance of sinus rhythm in patients undergoing concomitant cardiac surgery.

Methods and Results.
Ninety four consecutive patients with atrial fibrillation (paroxysmal, persistent or permanent) were followed up prospectivelly. The mean age was 67.8 years; there were 39 (41.5 %) women in the study group. Forty two patients (44.7 %) had paroxysmal or persistent atrial fibrillation and 52 (55.3 %) of them had permanent atrial fibrillation before surgery. Patients with permanent atrial fibrillation had significantly bigger preoperative left atrial diameter (51.2 versus 46.6 mm) and more severe tricuspid regurgitation (grade 2.3/4 versus grade 1.4/4) compared to the group with paroxysmal and persistent atrial fibrillation. Mitral valve surgery was significantly more frequent in patients with permanent atrial fibrillation too. Operations were performed between January 2005 and July 2006 using flexible argon-based cryoablative device. Sinus rhythm was achieved statistically significantly more frequently in patients with preoperative paroxysmal and persistent atrial fibrillation in comparison with patients with permanent atrial fibrillation –⁠ at discharge, 1, 3.5 and 6 months after operation (90.5–96.3 % versus 50–65.9 %). At 12 months it was only statistical trend (84.6 % versus 63.3 %). Kaplan–Meier vyvianalysis demonstrated a 79.4 % freedom from atrial fibrillation at 12 months. Preoperative atrial size and duration of atrial fibrillation were the most significant negative predictors of maintenance of sinus rhythm. Four patients (9.3 %) required postoperative permanent pacemaker placement. Ischemic stroke occured in 5 (5.3 %) patients. Thirty-day motality was 12.9 % (12 patients).

Conclusions.
Perioperative ablation of atrial fibrillation using cryoenergy is effective therapeutic method for restoring and maintenance of sinus rhythm in relatively high proportion of patients. The most significant predictors of late recurrence are preoperative atrial size and duration of atrial fibrillation. This non –⁠ pharmacological method should be routinely used in patients undergoing concomitant cardiac surgery.

Key words:
atrial fibrillation, maze procedure, cryoablation, arrhythmia surgery.