Authors: L. Muchová 1; L. Vítek 1; M. Jirsa 2 Authors‘ workplace: IV. interní klinika 1. LF UK a VFN, Praha 2Ústav klinické biochemie a laboratorní diagnostiky 1. LF UK a VFN, Praha3Laboratoř experimentální hepatologie Centra experimentální medicíny IKEM, Praha 1 Published in: Čas. Lék. čes. 2003; : 259-263 Category:
CEACAM1 (carcinoembryonic antigen-related cell adhesionmolecule 1) is a transmembrane glycoprotein belongingto the carcinoembryonic antigen (CEA) family and immunoglobulin superfamily. It is localized mainly in the apicaldomains of polarized epithelia, leukocytes and endothelia. With respect to this wide tissue distribution the researchis focused on the study of its biological functions. Structural and functional analyses show that the extracellulardomain of CEACAM1 participates in homotypic and heterotypic adhesion, whereas the cytoplasmic domain takespart in cell growth inhibition and signal transduction. Whereas CEA is highly expressed in adenocarcinomas,CEACAM1 expression is down regulated in many tumors and its tumor-supressive function was confirmed.CEACAM1 also takes part in insulin metabolism, acts as a promotor of cholesterol crystallization and serves as abinding receptor for certain bacterial strains in humans as well as hepatitis virus in mice.
Key words: CEACAM1, carcinoembryonic antigen, tumor, signal transduction, insulin, cholelithiasis, adhesion.
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