Authors: J. Kassa; J. Bajgar Authors‘ workplace: Vojenská lékařská akademie JEP, Hradec Králové Published in: Čas. Lék. čes. 1999; : 532-535 Category:
Background. Acute poisoning with the highly toxic organophosphorus agent, soman, is not treated satisfactorilyeven by the most modern antidotes.Methods and Results. In experiments on rats, the reactivating effect of a new asymmetric bispyridinium oxime BI-6was compared with widely used oximes HI-6 and obidoxime by investigating the changes of soman-inhibited acetylcho-linesterase activity in the diaphragm and various parts of the brain in rats up to three hours following soman challenge.Our findings confirm that the new oxime BI-6 is a more effective reactivator of soman-inhibited acetylcholines-terase than obidoxime but not as effective as the oxime HI-6 expecially in the peripheral compartment.Conclusions. The new oxime BI-6 is not as effective as HI-6 which seems to have definite advantages over otheroximes in the treatment of soman poisoning.
Key words: soman, BI-6, HI-6, obidoxime, acetylcholinesterase, diaphragm, brain, rat.
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