Multiple administration of medication and circulatory failure for malignant ventricular arrhythmias and impairment of liver function

Overview

Multiple administration of medication and circulatory failure for malignant ventricular arrhythmias and impairment of liver function. This article presents a case history of a polymorbid patient with serious arrhythmias in the ischemic substrate of the myocardium and circulatory failure. The patient was diagnosed with ventricular tachycardias, which led to repeated discharges of the implanted ICD. The patient was  receiving multiple medicaments concurrently (17 medicaments), a number of which (doxycykline, amiodarone, atorvastatin) had hepatotoxic characteristics. The increase in liver enzymes can be explained through the simultaneous administration of amiodarone, doxycycline and statine. Nor can the effect of ischemia during circulatory failure in the case of long-term tachyarrhythmias be omitted. The normalisation of liver function occurs following the curbing of serious circulatory arrhythmias and the significant reduction of pharmacotherapies.

Keywords:
malignant arrhythmias –⁠ liver impairment –⁠ administration of multiple medicaments