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Current guidelines for antiplatelet therapy in neurology


Authors: R. Herzig;  M. Král
Authors‘ workplace: Komplexní cerebrovaskulární centrum, Neurologická klinika LF UP a FN Olomouc
Published in: Kardiol Rev Int Med 2012, 14(2): 72-77

Overview

Stroke is one of the major causes of mortality and morbidity worldwide. Etiology of ischemic stroke is atherothrombotic in almost 70%, emboligenic in about 30%, other etiologies represent about 1–2%. European Stroke OrganisationGuidelines for the prevention of ischemic stroke and transient ischemic attack from the year 2008 are currently valid. According to these guidelines, antithrombotic therapy, comprising antiplatelet and anticoagulation therapy, is indicated in the primary and secondary prevention of ischemic stroke. Only acetylsalicylic acid (ASA) is being used in antiplatelet therapy in the primary prevention of atherothrombotic stroke. This is being used in the primary prevention of ischemic stroke also in younger patients with non-valvular atrial fibrillation and free of vascular risk factors. Antiplatelet therapy is being used in the secondary prevention of atherothrobotic ischemic stroke with combination of ASA with extended release dipyridamole or clopidogrel alone representing the therapy of choice and, with combination of clopidogrel with ASA being used in exceptional cases.

Keywords:
stroke – brain infarction – transient ischemic attack – prevention – antithrombotic drugs – anti­platelet drugs


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Labels
Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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