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Second consensus statement of European Atherosclerosis Society on low-density lipoproteins: statement of Czech Society for Atherosclerosis

Czech version

Authors: Pavel Kraml 1;  Michal Vrablík 2;  Vladimír Bláha 3;  Renata Cífková 4;  Tomáš Freiberger 5;  David Karásek 6;  Jan Piťha 7;  Hana Rosolová 8;  Vladimír Soška 9;  Tomáš Štulc 1;  Zuzana Urbanová Za Výbor Čsat 10
Authors‘ workplace: Interní klinika 3. LF a FN Královské Vinohrady, Praha 1;  III. interní klinika – endokrinologie a metabolismu 1. LF UK a VFN v Praze 2;  III. interní gerontometabolická klinika LF UK a FN Hradec Králové 3;  Centrum kardiovaskulární prevence 1. LF UK a Thomayerova nemocnice, Praha 4;  Centrum kardiovaskulární a transplantační chirurgie, Brno 5;  III. interní klinika – nefrologická, revmatologická a endokrinologická LF UP a FN Olomouc 6;  Interní klinika 2. LF UK a FN Motol a Laboratoř pro výzkum aterosklerózy IKEM, Praha 7;  II. interní klinika LF UK a FN Plzeň 8;  Oddělení klinické biochemie, II. interní klinika LF MU a FN u sv. Anny v Brně 9;  Klinika dětského a dorostového lékařství 1. LF UK a VFN v Praze 10
Published in: AtheroRev 2021; 6(1): 9-16
Category: Guidelines

Overview

In January 2020, the expert panel of the European Atherosclerosis Society released already its second consensus regarding Low Density Lipoproteins (LDL) and their relation to cardiovascular diseases based on atherosclerosis (ASCVD) [1]. This process begins in childhood and it has been proven that 71 % middle-aged males and 43 % middle-aged females already present the signs of subclinical atherosclerosis [1–3]. This statement discusses the causal role of LDL in the pathogenesis of atherosclerosis, their direct effect on the arterial wall with a cascade of processes leading to plaque formation, at the molecular, cellular and tissue levels. The mechanisms involved in the penetration of LDL through the arterial intima, their retention within the wall, as well as the subsequent factors of the immuno-inflammatory response have not been fully eluci­dated yet. The authors further note that the other lipoproteins containing apoprotein B including Triglyceride rich lipoproteins (TGRL) and their remnants – lipoproteins of intermediate density (IDL), and also Lp(a), have a causal relationship to the pathogenesis of atherosclerosis, however their significance is not part of this statement [5–8].

Keywords:

cardiovascular diseases based on atherosclerosis – low-density lipoproteins – intermediate-density lipoproteins – cardiovascular diseases based on atherosclerosis – low density lipoproteins – intermediate density lipoproteins

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Labels
Angiology Diabetology Internal medicine Cardiology General practitioner for adults
Úvodník
Important current information of consensus statement of EAS on low-density lipoproteins: editorial
Liečba dyslipidémií počas pandémie COVID-19
Antiatherosclerotic and antiinflammatory activities of SGLT2 inhibitors
Early cardiovascular risk intervention means cummulation of positive impacts in time
Why we need to improve serum levels of cholesterol after percutanneous coronary intervention
Low concentration of plasma cholesterol and type 2. diabetes mellitus
Comment on Low concentration of plasma cholesterol and type 2. diabetes mellitus
How we are (un)successful in the managing of dyslipidemia and why
Inclisiran: the first siRNA approved by European Medicines Agency for treatment of dyslipidemias
Rešerše zajímavých článků ze zahraniční literatury
24. virtuální kongres o ateroskleróze
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