Observational study of dyslipidemia management in the Czech Republic

Authors: Lukáš Zlatohlávek 1;  Michaela Šnejdrlová 1;  Ian Bridges 2;  Romana Šindelářová 3
Authors‘ workplace: III. interní klinika 1. LF UK a VFN v Praze 1;  Amgen Limited, Cambridge, Velká Británie 2;  Amgen s. r. o., Praha 3
Published in: AtheroRev 2019; 4(3): 162-169
Category: clinical studies


Introduction: A retrospective/prospective observational study was conducted to explore the current management of dyslipidemia in high and very high cardiovascular (CV) risk patients in Bulgaria, Czech Republic (CR), Croatia, Poland, Romania, Slovakia and Israel. We present data from the Czech subpopulation of the study.

Methods: Adult patients who attended their physician between June and December 2016 were enrolled at 11 sites in the CR if they were receiving lipid-modifying therapy and had a record of their LDL-C levels. Data were collected from medical records of the 12 months before enrolment. Prospective follow up lasted for up to 6 months.

Results: Out of the 201 Czech patients, mean age 67.3 years (SD 11.01), 128 were receiving LMT in secondary prevention, 32 after STEMI, 90 had diabetes and 27 familial hypercholesterolemia. 28 (13.9%) were classified as high risk and 173 (86.1%) as very high risk according to the ESC/EAS guidelines. Time since diagnosis was ≥5 years in 135 patients (67.2%). Almost all patients (192; 95.5%) were receiving statins, however, only in 40.8% (n = 82) high-intensity dosing regimen was prescribed. 18.4% of patients (n = 37) were treated with ezetimibe in combination with statins. 46.4% of high risk patients achieved their recommended LDL-C level < 2.6 mmol/L and 56.1% of very high risk patients achieved the target of < 1.8 mmol/L. Mean LDL-C at the first visit of the retrospective period was 2.55 mmol/L (SD 1.10).

Conclusions: The LDL-C serum concentrations were higher than the target recommended for prevention of fatal CV events in approximately a half of the Czech patients in high and very high CV risk. A large proportion of patients did not benefit from all available treatment options.


combination therapy – LDL-cholesterol – cardiovascular risk – dyslipidemia

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Angiology Diabetology Internal medicine Cardiology General practitioner for adults

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