Effect of novel anti-diabetic medication on cardiovascular risk
Metabolické centrum MUDr. Kataríny Rašlovej s. r. o., Bratislava
1; Koordinačné centrum pre familiárne hyperlipoproteinémie, SZU v Bratislave
AtheroRev 2019; 4(2): 91-93
Complex data on very high risk of cardiovascular morbidity and mortality in tape 2 diabetes were the reason why the Food and Drug Administration issued a guidance for industries requiring proof of cardiovascular safety for anti-diabetic medications. Since 2015, comprehensive results from clinical trials of two novel anti-diabetic classes SGLT2 inhibitors and GLP1 receptor agonists were published. The out-come trials showed not only low risk of hypoglycemia, potential to decrease body weight but this treatment was associated with lower risk of major cardiovascular endpoints as well as protection from progression of renal disease. These data had significant affect on decisons of treatment in type 2 diabetes subjects. In 2018, a consensus of ADA/EASD on management of hyperglycaemia was published. The consensus suggests that after metformin as the first line therapy, as the second line treatment should be added SGLT2 inhibitor or GLP1 receptor agonist because of their safety and data on lowering of cardiovascular and renal disease risk. This review article focuses on the two novel classes of anti-diabetic medication.
glucagon-like peptide 1 receptor agonist – sodium-glucose cotransporter-2 inhibitor – type 2 diabetes mellitus
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