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Contribution of brain dormancy to clinical signs of brain damage and the possibility of its treatment by zolpidem


Authors: Augustini Lucie 1;  Gabrhelík Tomáš 2;  Adamus Milan 1
Authors‘ workplace: Rehabilitační oddělení NsP Nový Jičín 1;  KARIM FN a LF UP v Olomouci, Olomouc 2
Published in: Anest. intenziv. Med., 24, 2013, č. 1, s. 26-32
Category: Anesthesiology - Review Article

Overview

Most of the various types of brain injuriy are supposed to be connected with neuroprotective supression of brain activity, so-called brain dormancy. The reason for this suppressed neuronal activity is protection of brain tissue from damage. However reduction in neuronal energy metabolism and function makes the clinical symptoms more serious. Later after brain injury inception, brain dormancy and suppression offer no benefit. Currently many experimental advances, pharmacological and non-pharmacological, are being made to achieve brain dormancy switch-off. One of drugs frequently used to restore brain function is zolpidem.

Keywords:
brain dormance – brain tissue damage – GABA – zolpidem – vegetative state – treatment of brain injury consequence


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Labels
Anaesthesiology, Resuscitation and Inten Intensive Care Medicine
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