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New role and rennaisance of branched chain aminoacids in intensive care


Authors: Zadák Zdeněk;  Hyšpler Radomír;  Tichá Alena
Published in: Anest. intenziv. Med., 23, 2012, č. 5, s. 253-258
Category: Intensive Care Medicine - Review Article

Overview

The branched chain amino acids valine, leucine and isoleucine are essential nutrients with more than nutritional effects. They are important mediators and structural components in proteosynthesis and they regulate hormonal functions. Leucine is a precursor in cholesterol synthesis and as such plays an important role in muscle tissue growth and in sarcopenia suppression. Older and recent data are reviewed and support wider utilization of branched chain amino acids in intensive care.

Keywords:
branched chain amino acids – valine – leucine – izoleucine – sarcopenia – catabolism – beta-hydroxy beta-methylbutyrate – critical condition


Sources

1. Ozgultekin, A., Turan, G., Durmus, Y., Dincer, E., Akgun, N. Comparison of the efficacy of parenteral glutamine and branched-chain amino acid solutions given as extra supplements in parallel to the enteral nutrition in head trauma. Clin. Nutr., 2008, 3, 3, p. 211–216.

2. Nissen, S., Abumrad, N. Nutritional role of the leucine metabolite beta-hydroxy beta-methylbutyrate (HMB). Nutr. Biochem., 1997, 8, 6, p. 300–311.

3. Harris, R. A., Joshi, M., Jeoung, N. H. Mechanism responsible for regulation of branched-chain amino acid catabolism. Biochem. Biophys. Res. Commun., 2004, 33, 2, p. 391–396.

4. Lal, H., Chugh, K. Metabolic and regulatory effects of branched chain amino acid supplementation. Nutr. Res., 1995, 15, 11, p. 1717–1733.

5. Holecek, M. Three targets of branched-chain amino acid supplementation in the treatment of liver disease. Nutrition, 2012, 26, 5, p. 482–490.

6. Freund, H. R., Hanani, M. The metabolic role of branched-chain amino acids. Nutrition, 2002, 18, 3, p. 287–288.

7. Marchesini, G. et al. Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: A double-bind, randomized trial. Gastroenterology, 2003, 124, 7, p. 1792–1801.

8. Merli, M., Nicolini, G., Angeloni, S., Riggio, O. Malnutrition is a risk factor in cirhotic patients undergoing surgery. Nutrition, 2002, 18, 17, p. 978–986.

9. Kim, H. Glutamine as an imunonutrient. Yonsei med. J., 2011, 52, 6, p. 892–897.

10. Leweling, H. et al. Hyperamoemia-induced depletion of glutamate and branched-chain amino acids in muscle and plasma. J. Hepatol., 1996, 25, 5, p. 756–762.

11. Ijichi, Ch., Matsumura, T., Tsuji, T., Eto, Y. Branched-chain amino acids promote albumin synthesis in rat primary hepatocytes through the mTOR signal transduction system. Biochem. Biophys. Res. Commun., 2003, 303, 1, p. 59–64.

12. Yoshizawa, F. New therapeutic strategy for amino acid medicine: notable functions of branched chain amino acids as biological regulators. J. Pharmacol. Sci., 2011, 118, 2, p. 149–155.

13. Kim, J. S., Wilson, J. M., Lee S. R. Dietary implications on mechanism of sarcopenia: roles of protein, amino acids and antioxidants. J. Nurl. Biochem., 2012, 21, 1, p. 1–13.

14. Nicastro, H. et al. Does branched-chain amino acids supplementation modulate skeletal muscle remodeling through inflammation modulation? Possible mechanisms of Action. J. Nutr. Metab., 2012, 2012, 1, p. 1–10.

15. Chanda, S., Mehendale, H. Role of nutrition in the survival after hepatotoxic injury. Toxicology, 1996, 111, 1–3, p. 163–178.

16. Kondrup, J. Nutrition in end stage liver disease. Best Pract. Res. Clin. Gastroenterol., 2006, 20, 3, p. 547–560.

17. Plauth, M. et al. ESPEN guidelines on parenteral nutrition: Hepatology. Clin. Nutr., 2009, 28, 4, p. 436–444.

18. Hwang, T. L., Chiang, Ch. L., Wang, P. N. Parenteral nutrition support after bone marrow transplantation: comparison of total and partial nutrition during the early posttransplantation period. Nutrition, 2001, 17, 9, p. 773–775.

19. King, P., Power, D. Branched chain amino/keto acid supplementation following severe burn injury: a preliminary report. Clin. Nutr., 1990, 9, 4, p. 226–230.

20. De Bandt, J. P., Cynober, L. Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis. J. Nutr., 2006, 136, 1 suppl, p. 308S–313S.

Labels
Anaesthesiology, Resuscitation and Inten Intensive Care Medicine
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