Authors: I. Schröderová 1; P. Nohel 1; D. Štěpánková 2 Authors‘ workplace: ARK, FN u sv. Anny v Brně, Pekařská 53, 656 91 Brno 2ARO a ECMO centrum FN Brno, pracoviště Dětská nemocnice 1 Published in: Anest. intenziv. Med., , 2004, č. 3, s. 130-139 Category:
Malignant hyperthermia is a serious complication of general anaesthesia. It is a genetically determined disposition with anautosomal dominant transfer. The development of MH is conditioned by the exposure to triggering agents – inhalationanaesthetics and suxamethonium.The nature ofMHis a disorder of calcium metabolismin sarcoplasmic reticulum receptorsin skeletal muscle. The review presents an overview of the history and current knowledge of pathophysiology, genetics,clinical picture and treatment of MH, gives important information for anaesthesia practice, summarizes current means ofpre-symptomatic testing and informs on the state of MH diagnostics world-wide and in the Czech Republic.
Key words: malignant hyperthermia – pre-symptomatic diagnostics – National Center for Diagnostics of MalignantHyperthermia in the Czech Republic
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