Severe Organophosphate Poisoning in Toddler

Overview

Intoxication of organophosphate insecticides is rare but life threating condition in young children. Muscarinic, nicotinic andCNS symptoms are manifestated in clinical presentation of acute poisoning due to irreversibile inhibition of acetylcholinesterasewhich leads to accumulation of acetylcholin in nervous system. We describe a 33-month-old boy with severe CNSdepression and hypotonia after organophosphate poisoning which was confirmed by toxicologic investigation of gastriccontens. On the basis of the result of a toxicologic investigation treatment with atropine and obidoxime was started to theclinical features of atropinization. Treatment with obidoxime was finished after four days. The boy was extubated on the 8thday of ventilatory support. Next day continuous treatment with atropine was stopped. Presented case-report of organophosphateintoxication in patient with typical clinical and biochemical findings document severity of this poisoning in youngchildren.

Key words:
organophosphate poisoning – CNS symptoms – atropine – obidoxime