Changes in Cholesterol Metabolism within a Few Days tlfter Severe Trauma

Czech version

Authors: B. Bakalář ¹; Z. Zadák ²; J. Pachl; R. Hyšpler ^{1 2}; J. Pažout ¹
Authors‘ workplace: ~ Univerzita Karlova, Klinika anesteziologie a resuscitace 3. LF a FN Královské Vinohrady, Praha, přednosta doc. Mi1Dr. Jan Pachl, CSc. z Univerzita Karlova, Klinika gerontologická a metabolická LF a FN Hradec Králové, přednosta prof. Mi1Dr. Zdeněk Zadák,
Published in: Anest. intenziv. Med., , 2002, č. 1, s. 10-11
Category:

Overview

We evaluated cholesterol and its precursors metabolism in 70 patiems within a few days after polytrauma. We observed low serum cholesterol levels (< 3.5 mmoUl) in all the patients, but these low values were not observed in the patients from the comrol group (P > 0.001). The reasons for hypocholesterolaemia were haemodilution during the earliest 24 hours after trauma, low rafe of cholesterol and its precursors synthesis and the consumption of serum cholesterol in an unknown proces. Average time for which hypocholesterolaemia lasted was 9±3.2 days.

Key words:
hypocholesterolaemia - polytrauma - squalene - lathosterol - lanostero

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