Pathophysiology of Gut Failure in MODS

Overview

This review article discusses pathophysiology of gut failure and its relation to multi-organ failure (MOF). Triggering factors are reviewed withpathophysiologic mechanisms which take part on the increase of intestinal wall permeability, leading to translocation of bacteria or their toxins fromthe intestinal lumen. In conclusion, the authors state that in spite of deemed connection between bacterial translocation, increased intestinal wallpermeability and the development of MOSF, there is no clear definition or evidence of that relationship.

Key words:
bacterial translocation – intestinal wall permeability