Lymphocytic activation in critically ill septic patients during CVVHD

Czech version

Authors: M. Holub ¹; M. Kolář ¹; M. Helcl ²; P. Pudil ³
Authors‘ workplace: III. klinika infekčních a tropických nemocí 1. LF UK, přednosta doc. MUDr. A. Lobovská, CSc. 2 Infekční klinika FN Bulovka, primář MUDr. Hana Roháčová3 Ústav teorie informace a automatizace AV ČR, ředitel prof. ing. Vladimír Kučera, DrSc.
Published in: Anest. intenziv. Med., , 1999, č. 1, s. 33-35
Category:

Overview

In 10 critically ill septic patients treated with continuous veno-venous hemodiafiltration (CVVHD), we investigated lymphocytic activation moleculesHLA-DR. The control group consisted of 35 septic patients not treated with CVVHD. The average expression of HLA-DR molecules in critically illpatients before introducing hemodiafiltration was significantly lower than in the control group (p = 0,0394). 24 hours after introducing CVVHD, thevalues of expression were significantly higher than before aplying the method (p = 0,0034). 3 days after discontinuing CVVHD the expression stayedsignificantly increased when compared to the values obtained before using the method (p = 0,0024).During CVVHD an activation of cellular immunity was observed. The activation in critically ill septic patients is significantly lower when comparedto septic patients, that do not require intensive care.

Key words:
hemodiafiltration – HLA-DR – sepsis – lymphocytes

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