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How and when does the reaction to gluten begin in coeliac disease? A new Canadian study offers potential answers

6. 11. 2024 Source:

As is well known, coeliac disease is a systemic autoimmune disorder characterised by damage to intestinal epithelial cells (IEC). Canadian researchers have sought to uncover the relationship between intestinal epithelial cells and T lymphocyte activation in this disease. The results of their work provide hope for the potential development of an effective therapy.

Could Artificial Intelligence Help with Emergency Department Triage in the Future?

A new study by researchers from the University of California, San Francisco, is one of the few to use real clinical data to test the potential of artificial intelligence (AI) in healthcare. How did…

5. 11. 2024 Source: proLékaře.cz

Results of Prophylactic Treatment of Severe von Willebrand Disease with Recombinant vWF

The phase III study cited below evaluated the efficacy and safety of 12-month prophylaxis with recombinant von Willebrand factor (rvWF) in 23 patients with severe von Willebrand disease (vWD), who had...

4. 11. 2024 Source: Hemophilia

The Brain, Too, Has Its Midlife Crisis. How Do These Changes Relate to the Risk of Dementia in Old Age?

The human brain undergoes rapid changes during certain developmental periods. Childhood, adolescence, and advanced old age undoubtedly belong to these. For much of adulthood, it seems that nothing…

31. 10. 2024 Source:

Excellent effect of sotorasib in a higher line of treatment in a patient with NSCLC with G12C mutation of KRAS –⁠ a case study

We present a case study of an elderly patient with non-small cell lung cancer (NSCLC) treated with the selective KRASG12C inhibitor sotorasib in the 5th line of oncological treatment, but with a very…

30. 10. 2024 Source: Lung Cancer

Fluoroscopically Calibrated 3D-Printed Tools Increase Osteotomy Precision During Tumor Resection Near Joints

The area around the knee is a common site for malignant bone tumors, such as osteosarcomas. Their removal typically involves R0 resection, which is the complete removal of tumor tissue. Because these…

30. 10. 2024 Source: proLékaře.cz

Intermittent Fasting May Carry Significant Health Risks

Results from an observational study presented at this year’s American Heart Association (AHA) Congress revealed surprising findings. Eating restricted to an 8-hour window daily—a popular form of…

29. 10. 2024 Source:

Smaller Volume and Faster Infusion Rate of aPCC: What Do Current Data Say About This Modification?

Administering an infusion of activated prothrombin complex concentrate (aPCC) at the standardized rate of 2 U/kg/min can be time-consuming, especially when repeated applications are needed. The authors...

6. 10. 2024 Source: Hemophilia

Portal Vein Thrombosis as a Complication of COVID-19 Infection –⁠ A Case Study

COVID-19 Infection is Associated with a Higher Risk of Thrombotic Complications. Many cases of deep vein thrombosis or pulmonary embolism have been described in connection with this disease, but portal...

4. 10. 2024 Source: proLékaře.cz

Experience with 20% subcutaneous immunoglobulin in the treatment of primary immunodeficiency

Patients with primary antibody deficiency are administered immunoglobulin (Ig) replacement therapy to prevent recurrent infections. An open-label phase III study evaluated the efficacy and safety of a...

12. 9. 2024 Source: proLékaře.cz

The Benefit of Liposomal Irinotecan in the Treatment of Pancreatic Cancer in a Young Patient –⁠ A Case Study

Pancreatic tumors continue to be a challenge in modern oncology. Due to the asymptomatic nature of early stages, most cases are diagnosed in advanced stages. The five-year survival rate of patients…

9. 9. 2024 Source: Treatment of Gastrointestinal Carcinomas

Each Missed Dose of Thromboprophylaxis in Trauma Patients Significantly Increases the Risk of VTE

Available data shows that enoxaparin prophylaxis effectively reduces the incidence of venous thromboembolism (VTE) without significantly increasing the risk of bleeding. Despite this evidence, the administration...

6. 9. 2024 Source: proLékaře.cz

Biosimilars in the Prophylaxis of Venous Thromboembolism

Hospitalized patients with internal diseases or after surgery have an increased risk of venous thromboembolism (VTE). The first-line prophylaxis for patients at high risk of thrombosis with an acceptable...

4. 9. 2024 Source: proLékaře.cz

Technology allows children in palliative care to escape from the hospital room for a while

Children's palliative care is a field that is just developing in our country. Palliative teams are inspired by foreign practices and strive to integrate their own experiences and those of their…

22. 7. 2024 Source: proLékaře.cz

With MD Eva Drbohlavová on Innovations in the Treatment of von Willebrand Disease and Improving Patients' Quality of Life

Von Willebrand Disease (vWD), as the most common congenital bleeding disorder, remains underdiagnosed. However, thanks to new insights and advances in genetic testing, both diagnosis and long-term…

17. 7. 2024 Source: Von Willebrand Disease

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