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Jednohubky z klinického výzkumu – 2026/1

“Clinical Research Bites” –⁠ 2026/1

8. 1. 2026 Source: proLékaře.cz

The first “bites” of the year highlight, right at the start, the benefits of a month of alcohol abstinence. Alongside this, they move from the latest findings on outcomes of proton therapy for oropharyngeal cancer through predictors of dementia all the way to prodromal dreams.

Reprogramming the Blood–Brain Barrier in an Alzheimer’s Disease Model

Disruption of transport mechanisms across the blood–brain barrier is considered one of the key factors contributing to β-amyloid accumulation in the brain. A new experimental study shows that…

7. 1. 2026 Source: proLékaře.cz

Euthanasia at the Request of Patients With Dementia? Opinions Differ

An international study examined the views of clinical physicians from six countries regarding the acceptability of euthanasia for people living with dementia. The survey revealed substantial…

5. 1. 2026 Source: proLékaře.cz

Can AI Help Accelerate the Development of Antibiotics for Gonorrhea and MRSA?

The overuse of antibiotics has helped bacteria become resistant to them. In the fight against antibiotic resistance, the involvement of artificial intelligence in the development of new drugs could…

2. 1. 2026 Source:

BioCog Test: Ten Minutes to Orient Yourself in a Patient’s Cognitive Status

The patient-completed digital BioCog test was developed as a rapid and standardized alternative to paper-based methods for detecting cognitive decline. A study evaluated its accuracy in primary care…

29. 12. 2025 Source: proLékaře.cz

Jednohubky z klinického výzkumu – 2025/39

“Clinical Research Bites” –⁠ 2025/39

In the final “bites” of this year, we start by disappointing devoted beer lovers. On the other hand, advances in research may simplify the management of care for patients with breast cancer or severe...

18. 12. 2025 Source: proLékaře.cz

Kmenové buňky otevírají dveře k možnostem léčby roztroušené sklerózy

Stem Cells Open the Door to New Treatment Possibilities for Multiple Sclerosis

Multiple sclerosis (MS) remains a daunting adversary for most patients. This disease, which affects the brain, spinal cord, and optic nerve, gradually damages the protective myelin sheath of neurons…

17. 12. 2025 Source: proLékaře.cz

How Can VR Glasses Serve as a Diagnostic Tool for Dementia?

A recent study by researchers from the German Center for Neurodegenerative Diseases (DZNE) identified a possible link between impaired spatial orientation abilities and an increased risk of dementia…

15. 12. 2025 Source: proLékaře.cz

Nová platforma urychlí diagnostiku Alzheimerovy choroby

New Platform May Accelerate Diagnosis of Alzheimer’s Disease

A recent study published in Biosensors & Bioelectronics describes an innovation that could accelerate the diagnosis of Alzheimer’s disease (AD) and improve treatment outcomes. Researchers at the…

5. 12. 2025 Source: proLékaře.cz

Speciálně navržené videohry mohou podpořit duševní zdraví dětí a dospívajících

Specially Designed Video Games May Support Mental Health in Children and Adolescents

A review of published studies from 2011–2024 conducted by a team at the Johns Hopkins Children’s Center shows that certain video games developed as digital interventions may serve as a useful adjunct...

3. 12. 2025 Source: proLékaře.cz

Jaké jsou nové směry u Gerstmann-Sträussler-Scheinkerova syndromu?

What Are the New Directions in Gerstmann-Sträussler-Scheinker Syndrome?

Gerstmann-Sträussler-Scheinker syndrome (GSS) is a prion disease of the brain. It is an extremely rare but invariably fatal disorder in which a normal protein becomes a destructive pathogen. Although…

28. 11. 2025 Source: proLékaře.cz

Barthův syndrom má první schválené léčivo, zatím v USA

Barth Syndrome Has Its First Approved Therapy —⁠ For Now Only in the U.S.

The accelerated approval of elamipretide by the U.S. FDA marks a historic milestone in the treatment of mitochondrial diseases. It is the first therapy targeting cardiolipin dysfunction and the first…

26. 11. 2025 Source:

CHOPN a OSA – dvojice, která zvedá riziko smrti do pěti let o třetinu

COPD and OSA –⁠ A Deadly Duo That Raises Five-Year Mortality by One-Third

On the occasion of this year’s World Chronic Obstructive Pulmonary Disease (COPD) Day, observed on November 19, Czech pulmonologists drew attention to a new topic: the dangerous overlap of COPD and…

24. 11. 2025 Source: proLékaře.cz

Karcinomy děložního hrdla a orofaryngu způsobené HPV – proč se liší a co s tím?

HPV-Related Cervical and Oropharyngeal Cancers: Why They Differ –⁠ and What It Means for Clinical Practice

The same virus, yet tumors behave very differently. HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) is highly radiosensitive, enabling treatment de-escalation and thus lowering toxicity.…

19. 11. 2025 Source: proLékaře.cz

MUDr. Marek Štefan: Spolupráce s farmaceuty je při léčbě antibiotiky zásadní

MUDr. Marek Štefan: Cooperation With Pharmacists Is Essential in Antibiotic Therapy

In September, the Congress of Clinical Microbiology, Infectious Diseases and Epidemiology (KMINE) took place in Hradec Králové. What insights did it bring regarding current and emerging antibiotic…

10. 11. 2025 Source:

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