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Levothyroxine and the Interchangeability of Preparations Containing It

6. 11. 2020 Source: Thyroid Disorders

Levothyroxine is a synthetic thyroid hormone used to treat patients with hypothyroidism, which affects approximately 1-2% of the younger population and increases with age, especially in women. Levothyroxine is a drug with a narrow therapeutic window, and its bioavailability is influenced by many factors, including consumed foods, medications, and beverages.

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Desirable Side Effects of Antidiabetics

The days when diabetology was a field solely focused on normalizing blood sugar levels are long gone. Today, the approach in diabetology increasingly prioritizes influencing the patient's overall…

6. 11. 2020 Source: Diabetes

Benefit of a single intra-articular injection of hyaluronic acid in the treatment of osteoarthritis

Viscosupplementation serves as a minimally invasive procedure to restore the rheological properties of synovial fluid and alleviate pain in patients with symptomatic osteoarthritis (OA). We now have…

6. 11. 2020 Source: Osteoarthritis

Efficacy and Safety of Single-Application Hyaluronic Acid in Osteoarthritis Therapy

Causal therapy for osteoarthritis does not yet exist. Patients suffering from progressive joint disease are thus dependent on symptomatic medications that alleviate symptoms and partially slow the…

6. 11. 2020 Source: Osteoarthritis

Enoxaparin in Weight-Based Dosing for Thromboprophylaxis in Hospitalized Cancer Patients

Cancer patients are at higher risk of developing thromboembolic disease during hospitalization. Currently, there is not enough evidence supporting the efficacy and safety of the standard fixed dose…

6. 11. 2020 Source: Thromboprophylaxis

Neoadjuvant Immunotherapy in Resectable Non-Small Cell Lung Cancer

Antibodies against the programmed cell death protein 1 (PD-1) improve the survival of patients with advanced non-small cell lung cancer (NSCLC). However, their use has not yet been tested in patients…

6. 11. 2020 Source: Immunotherapy in Oncology

Impact of Alpha-1 Antitrypsin Deficiency on Quality of Life and Mental Health of Patients

The clinical manifestation of alpha-1 antitrypsin deficiency and its impact on quality of life are highly heterogeneous. This contribution by pulmonologist Robert Sandhaus summarizes interesting…

3. 11. 2020 Source: Deficiency of Alpha-1-Antitrypsin

COVID-19 and Immune Thrombocytopenic Purpura −⁠ Spanish Experience Suggests Surprising Connections

In a retrospective study examining the impact of COVID-19 on immune thrombocytopenic purpura, Spanish authors surprisingly observed a paradoxical effect.

2. 11. 2020 Source: Immune Thrombocytopenia

Care of Dental Dentures According to the Recommendations of the American Society of Dental Prosthetists

Dental dentures are the most common solution for missing teeth in the jaw. They should serve patients for several years, so proper care is essential. Therefore, dental professionals should not only…

2. 11. 2020 Source: Optimal Care of Dentures

Current Insights into the Antispasmodic and Analgesic Effects of Metamizole on the Gastrointestinal Tract

Brazilian authors published a review of available information on the mechanism of action of metamizole, its impact on gastrointestinal tract motility, its effect on the gastric mucosa, and its…

2. 11. 2020 Source: Analgesia

Impact of Thyroid Dysfunction on the Cardiovascular System in Elderly Patients

The incidence of thyroid disease increases with age. In the Czech Republic, up to 5% of the population suffers from hypothyroidism, and the prevalence of hyperthyroidism is estimated at 0.2-1%. The…

2. 11. 2020 Source: Thyroid Disorders

Rurioctocog alfa pegol in previously treated patients with severe hemophilia A: What findings did the long-term continuation study bring?

Rurioctocog alfa pegol (Adynovi) is a recombinant coagulation factor VIII modified by pegylation, which results in an approximately 1.5× prolonged biological half-life compared to standard half-life…

2. 11. 2020 Source: Hemophilia

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