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News Efficacy of Ceftazidime/Avibactam in the Treatment of Infections Caused by Carbapenemase-Producing Enterobacteria

Infections caused by carbapenemase-producing enterobacteria are associated with high mortality, and their incidence continues to rise. The study presented below investigated the efficacy of therapy with the combination of ceftazidime/avibactam (a third-generation cephalosporin and a beta-lactamase inhibitor) in treating these infections compared to the 'best available antibiotic therapy' (BAT).

Source: Anti-Infectives 22. 8. 2023

News Subcutaneous Immunoglobulin Substitution in Ig-Naive Patients with PID –⁠ Available Efficacy and Safety Data

The prevalence of primary immunodeficiencies (PID) is estimated at 1 : 10,000. Below, we summarize the available findings on the efficacy and safety of subcutaneous immunoglobulin substitution in Ig-naive patients (i.e., without prior immunoglobulin substitution).

Source: Primary and Secondary Immunodeficiencies 3. 4. 2023

News Technology as an Aid in Home Oral Care

Good oral hygiene is a prerequisite for good health, both in the mouth area and in terms of overall condition. To make it more effective and easier, it is now possible to use technologically advanced tools that allow users to achieve and maintain high hygiene standards in regular daily care.

Source: Dental Care 22. 2. 2023

News Efficacy and Safety of Ultrahypofractionated Proton Therapy in the Treatment of Prostate Cancer in Real-World Czech Practice

A team from the Prague Proton Therapy Center, led by Associate Professor Jiří Kubeš, published a study with nearly 300 patients in the prestigious International Journal of Radiation Oncology, Biology, Physics. It demonstrates the significant efficacy and low toxicity of the ultrahypofractionated proton therapy regimen in patients with prostate cancer. We summarize the main results.

Source: Proton Radiotherapy 5. 4. 2023

News AAD 2023: Efficacy of Bimekizumab in the Treatment of Hidradenitis Suppurativa

At the latest annual congress of the American Academy of Dermatology (AAD), held March 17-22, 2023 in New Orleans, the results of the phase III BE HEARD I and II studies were presented among late-breaking presentations. The studies demonstrate the safety and high efficacy of bimekizumab in the treatment of adults with moderate to severe hidradenitis suppurativa (HS).

Source: Psoriasis 7. 4. 2023

News Measurement of Serum Trough Levels of IgG as an Adequate and Beneficial Indicator for Assessing the Pharmacokinetics of Subcutaneously Administered Products

For many patients with primary immunodeficiency, lifelong immunoglobulin substitution is essential to reduce the frequency of severe infections. Subcutaneous home administration is better accepted by patients. However, dosing needs to be customized to the patient. The study presented below may help make therapy individualization easier for doctors and more tolerable for patients.

Source: Primary and Secondary Immunodeficiencies 11. 4. 2023

News Dosing and Consumption of rFVIII Products with Extended Half-life in Patients with Hemophilia A in Real-World Practice

Based on real-world data from the USA, a recently published study compared two recombinant human factor VIII (rFVIII) products with extended half-life (EHL) –⁠ efmoroctocog alfa and rurioctocog alfa pegol, in terms of dosing frequency, weekly consumption, and dose variability.

Source: Hemophilia 11. 4. 2023

News Screenings of Lung Cancer and COPD are Significant. What Do the Latest Data from Czechia Say?

At the end of January, an expert seminar was held, focusing on updates in the treatment of respiratory diseases. During this event, the head of the Pulmonary Clinic at LF UK and FN Hradec Králové, Associate Professor MUDr. Vladimír Koblížek, Ph.D., gave a lecture on the current Czech findings from lung cancer screenings and a project aimed at the early detection of chronic obstructive pulmonary disease (COPD).

Source: Cough Therapy 12. 4. 2023

News Compression Therapy with Zinc Oxide Dressings in Dermatology

Zinc oxide dressings have a long-standing tradition and continue to find their place in modern dermatology. Compression therapy is the cornerstone of conservative treatment for chronic venous insufficiency and lymphatic insufficiency and should not be overlooked even at the stage of venous leg ulcers.

Source: Wound Healing 10. 5. 2023

News Diagnosis and Management of Therapy for a Breastfeeding Patient with Significant Elevation of Liver Enzymes Postpartum –⁠ Interactive Case Study

In the following case study, we present a specific approach to a patient who developed a significant elevation of liver enzymes after childbirth. Through interactive elements, you can try out how you would proceed in diagnosing and treating this case.

Source: Primary Biliary Cholangitis 14. 4. 2023

News Echocardiography in the Diagnosis of Cardiac Amyloidosis

Cardiac amyloidosis remains a diagnostic challenge that requires great clinical vigilance. The imaging method of choice for evaluating heart failure suspected of amyloidosis is echocardiography. What findings are typical for patients with amyloidosis?

Source: Amyloidosis 17. 4. 2023

News Ligamentous Changes as a Harbinger of Cardiac Amyloidosis –⁠ Histopathological and Clinical Study

Amyloid deposits can be present in various types of tissue. Their accumulation in connective tissue can lead to pathological changes resulting in the rupture of stressed structures (e.g., the Achilles tendon) or stenosis in areas where blood vessels and nerves pass through (e.g., carpal tunnel syndrome). Swedish doctors focused on patients with lumbar spinal stenosis to analyze how often this diagnosis is associated with amyloid deposits.

Source: Amyloidosis 10. 4. 2023

News Early Tumor Regression as a Marker of Overall Survival in First-Line Treatment of mCRC

In the treatment of metastatic colorectal cancer (mCRC), prognostic factors besides overall survival (OS) and progression-free survival (PFS) include early tumor regression (ETS) and depth of response (DpR). Japanese authors presented the results of an analysis at the European Society for Clinical Oncology (ESMO) congress in September 2022, which evaluated the correlation between ETS, DpR, and OS/PFS in patients with wild-type RAS mCRC from the PARADIGM study.

Source: Colorectal Cancer 21. 4. 2023

News Is Obesity a Universal Phenotype in Children with Type 2 Diabetes?

What is the global prevalence of obesity in children and adolescents suffering from type 2 diabetes mellitus (T2DM)? Does the occurrence of obesity in pediatric T2DM correlate with gender or race? And how is obesity in T2DM under 18 years of age associated with glycemic control and dyslipidemia? These questions have been addressed by Canadian authors in their recently published systematic review and meta-analysis, which deals with various issues related to childhood obesity.

Source: Modern Treatment of Diabetes 19. 4. 2023

News Adherence to Treatment of Multiple Sclerosis: How to Enhance It and What Interesting Insights Emerged from Current Research?

Therapeutic options for patients with multiple sclerosis (MS) utilizing disease-modifying drugs (DMDs) have continued to expand in recent years. However, achieving their full benefit is critically dependent on adherence to treatment. Nonadherence is demonstrably linked to an increased risk of relapses, faster progression of disability, higher treatment costs, and higher mortality. We present a summary of factors affecting adherence to treatment in MS patients, including the influence of the chosen therapy from a 2022 review and subsequent studies.

Source: Multiple Sclerosis 24. 4. 2023