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News Even a Single Epileptic Seizure is Too Much

Focal epileptic seizures resistant to pharmacotherapy represent an ongoing unmet medical need.

Source: Epilepsy 7. 4. 2022

News Insufficiently Controlled Epilepsy Reduces Quality and Length of Life

The effects of uncontrolled epilepsy far exceed the moment of a seizure, having a substantial impact on the psychological and physical well-being of patients. These individuals often sustain injuries during seizures, leading to reduced mobility, a higher risk of associated diseases, and premature death.

Source: Epilepsy 7. 4. 2022

News Can Erdostein Help in Treating Infections Related to Biofilm Formation?

One of the reasons for the very difficult treatment of diseases caused by resistant bacterial strains is the significant ability of these infection-causing agents to form biofilms. What exactly is a biofilm? Which bacteria are likely to form it, and how can erdostein help in the fight against it?

Source: Cough Therapy 8. 4. 2022

News Administration of Erdosteine After Severe Course of COVID-19 in the Early Period After Patient Discharge From Medical Facility

Erdosteine is a mucomodulatory drug used in the therapy of various acute and chronic respiratory diseases. Its mechanism of action is considered complex based on available evidence, encompassing antioxidant and antibacterial effects along with its mucolytic effect. Two clinical studies assessed changes in respiratory distress parameters and quality of life in patients taking this medication in the early period after discharge from medical facilities where they were hospitalized for severe COVID-19 (respiratory failure, pneumonia).

Source: Cough Therapy 8. 4. 2022

News Monocyte Distribution Width as an Early Indicator of Sepsis in ICU Patients

Authors of a Franco-Spanish study propose using the monocyte distribution width along with leukocyte count as a screening test to refine the early diagnosis of sepsis in intensive care unit (ICU) patients based on their research findings.

Source: Because 9. 4. 2022

News Curative Potential of Neoadjuvant Denosumab in the Treatment of Giant Cell Spinal Tumor? A Case Study

Portuguese authors present a case study of a young woman diagnosed with a giant cell spinal tumor who achieved complete histological remission following denosumab treatment.

Source: Prevention of Bone Events 9. 4. 2022

News Prevention of Skeletal Events in the Therapy of Patients with Advanced Prostate Cancer

Prostate cancer most commonly forms metastases in the bones. In patients with this advanced disease, skeletal events occur, negatively affecting their quality of life. Zoledronic acid and denosumab are used to prevent their occurrence, and their results in this indication were evaluated and compared in the cited study below.

Source: Prevention of Bone Events 9. 4. 2022

News The Immune System in the Pathophysiology of ITP

From the perspective of the pathophysiology of immune thrombocytopenia (ITP), it appears that the etiology of this disease is very complex and involves both antibody and cellular immunity.

Source: Immune Thrombocytopenia 9. 4. 2022

News Over 10 Years of Experience with TPO-RA in the Treatment of Immune Thrombocytopenia

Medications from the group of thrombopoietin receptor agonists (TPO-RA) have become an integral part of the therapy for patients with immune thrombocytopenia (ITP) over the past more than 10 years. Their administration represents a new approach compared to the previous, long-established treatment, and has significantly changed the prognosis of the disease in many patients.

Source: Immune Thrombocytopenia 9. 4. 2022

News Diagnosis and Management of Interstitial Lung Processes Associated with Rheumatoid Arthritis

Interstitial lung processes (ILD) are common yet insufficiently diagnosed complications of rheumatoid arthritis (RA), significantly increasing the morbidity and mortality of patients. ILD can occur at any stage of RA, presenting a diverse clinical picture. Usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) are the most common findings on high-resolution CT (HRCT). Some patients with RA-associated ILD may exhibit a progressive phenotype characterized by expanding fibrotic changes on HRCT, declining lung function, worsening respiratory symptoms, and early mortality. A recently published review summarizes strategies for screening, monitoring, and managing ILD in RA.

Source: Progressive Interstitial Pulmonary Processes 3. 1. 2024

News Potential of Enoxaparin to Maintain A-V Shunt Patency According to the SEP Protocol

A newly published study by authors from Singapore focused on the ability of the SEP protocol –⁠ short-term low-dose enoxaparin administration based on body weight –⁠ to maintain the patency of an arteriovenous (A-V) shunt after recurrent thrombosis.

Source: Thromboprophylaxis 3. 1. 2024

News How to Navigate the Challenges of Anticoagulant Therapy in Pregnant Women −⁠ A Case Study

Every carrier of a mechanical heart valve is also on anticoagulant therapy. Warfarin is most commonly used for this purpose, but it is not suitable during pregnancy due to the risk of embryopathy. So how should we approach patients with artificial valves who wish to become pregnant? The following case study presents one option.

Source: Thromboprophylaxis 3. 1. 2024

News Position of Enoxaparin and DOACs in Extended Prevention of VTE After Surgeries for Gynecological Malignancies

The prophylaxis of venous thromboembolism is a crucial part of postoperative management in oncological diseases, including gynecological malignancies. A newly published survey study conducted in Australia and New Zealand focused precisely on these. The authors were interested in different types of postoperative prophylactic regimens and the potential use of direct oral anticoagulants (DOACs) in them.

Source: Thromboprophylaxis 3. 1. 2024

News Issues of Adherence to Thromboprophylaxis with Enoxaparin in Patients with Sickle Cell Disease

Thromboembolic disease is one of the common complications in patients with sickle cell disease (SCD). However, a recently published study shows that patient adherence to prescribed thromboprophylaxis is not very high.

Source: Thromboprophylaxis 3. 1. 2024

News A Decade of Therapy Targeting B Lymphocytes in MS

Ocrelizumab is not only a pioneer but also a highly effective and still promising modality for the treatment of multiple sclerosis (MS) with excellent patient adherence and persistence.

Source: Neurology - Multiple Sclerosis 3. 1. 2024