https:/#/nc.emagedd.www/ - Search

News Hybrid Cooperative Complexes in the Treatment of Osteoarthritis

Intra-articular application of corticosteroids and hyaluronic acid is part of the treatment of osteoarthritis (OA) in patients for whom oral or topical treatment does not provide sufficient response. The following text addresses the lubricating and protective properties of synovial fluid and the related choice of appropriate intra-articular viscosupplementation, with emphasis on innovative molecules with high concentrations of hyaluronic acid and low viscosity.

Source: Pain Management 18. 6. 2024

News Inhibition of Mutated KRAS Protein as a New Option for Targeted Treatment of Non-Small Cell Lung Cancer

RAS proteins are molecular switches for several intracellular signaling pathways. Their dysfunction due to mutation leads to the development and progression of malignant diseases such as colon or lung cancers. At the beginning of 2022, the inhibitor of the mutated KRAS protein, sotorasib, was approved. The following article outlines the effect of this first representative of a new drug group and its potential in the treatment of non-small cell lung cancer (NSCLC).

Source: Lung Cancer 9. 11. 2023

News Dupilumab Now Covered for Atopic Dermatitis in Children Older Than 6 Years

Dupilumab is now fully covered by public health insurance for pediatric patients from 6 years old with atopic dermatitis. This opens up a new possibility for pediatric patients with this condition to improve their quality of life.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 22. 1. 2022

News The Future and Prospects of Type 2 Diabetes Therapy: Can We Fully Cure It with Endoscopy or Genetics?

Diabetes mellitus (DM) cannot be cured, but it can be successfully treated... Will we rewrite this textbook fact passed down for years in the future? Will we be able to completely cure type 2 diabetes mellitus (T2DM) one day? The Prague Institute for Clinical and Experimental Medicine (IKEM) sees endoscopic procedures as one of the promising paths and is preparing to test this groundbreaking method of therapy.

Source: Modern Treatment of Diabetes 6. 5. 2021

News The Presence of COPD Worsens the Course of COVID-19 –⁠ Results of Epidemiological Studies

Among the at-risk populations during the current COVID-19 pandemic are older individuals and those suffering from chronic comorbidities. The presence of chronic obstructive pulmonary disease (COPD), according to available data, represents a negative prognostic factor increasing the risk of severe course and mortality.

Source: Treatment of Asthma and COPD 8. 4. 2020

News Current Approaches to COPD Therapy According to GOLD Recommendations and in the Conditions of Czech Practice

Chronic Obstructive Pulmonary Disease (COPD) represents a significant global cause of morbidity and mortality with a high prevalence that is expected to increase significantly in the coming years. Since it is a preventable and treatable disease, active therapy, which is globally guided by international recommendations based on the GOLD strategy, plays an important role. However, in the following article, we will also place these recommendations in the current context of care for these patients in the Czech Republic.

Source: Treatment of Asthma and COPD 15. 11. 2022

News Monitoring Limits in Prescribing Incontinence Aids is Essential

The amendment to the Public Health Insurance Act, which came into effect in December 2019, brought many changes in the reimbursement of medical aids through prescriptions. The methodology for determining the degree of incontinence has changed, and it is now also possible to combine aids according to the individual needs of the patient. We summarize other novelties related to limits issues in the following text.

Source: Incontinence 29. 2. 2020

News Eletriptan and Its Role in Acute Migraine Therapy

In the acute treatment of moderate to severe migraine attacks, medications from the triptan group are primarily used. The following article summarizes important findings about eletriptan and its key results in clinical studies.

Source: Treatment of Severe Migraine 10. 5. 2022

News Wound Treatment Without Pain? A Rinse Solution Can Help

Patients dealing with a healing wound may fear painful dressing changes. The wound bed is exposed and highly sensitive to pain due to damaged nerve endings. By using a rinse solution, however, we can eliminate the traumatic removal of the primary dressing, making the dressing change gentler for the patient. But which solutions are suitable for this purpose and which are not?

Source: Wound Healing 25. 2. 2022

News How to Set Individual Treatment Goals for Type 2 Diabetes?

Treatment goals for type 2 diabetes should always be set individually. In practice, this mainly involves an indicator of the success of long-term compensation –⁠ glycated hemoglobin (HbA_1c). Recommendations for the diagnosis and treatment of diabetes for general practitioners from 2020 list different target HbA_1c values according to the risk of hypoglycemia and other parameters. They also recall different target values for fit, frail, and dependent seniors.

Source: Diabetes 28. 8. 2020

News Metamizole vs. Tramadol in Postoperative Analgesia

Metamizole and tramadol are well-known analgesics that have been used in practice for a long time. Interesting insights into these substances were provided by the studies presented below. Spanish doctors evaluated the efficacy and safety of metamizole compared to tramadol in postoperative analgesia after abdominal hysterectomy. German researchers were interested in the possibility of applying a combination of these drugs in an analgesic regime controlled by the patient.

Source: Analgesia 19. 4. 2021

News Current European Recommendations for the Treatment of Renal Colic Due to Urolithiasis

At the annual congress in Milan in 2023, new recommendations from the European Association of Urology (EAU) for the acute treatment of patients with renal colic were presented. We summarize the key points concerning primarily analgesic treatment.

Source: Analgesia 21. 6. 2024

News Long-term Efficacy and Safety of Mavacamten in the Treatment of Obstructive HCM

Interim results of the MAVA-LTE study provide the latest data on the long-term safety and efficacy of symptomatic treatment with mavacamten for obstructive hypertrophic cardiomyopathy (oHCM), with the longest follow-up period nearly 2.5 years. For clinical practice, the long-term reduction of left ventricular outflow tract (LVOT) obstruction and good tolerability of the treatment are particularly favorable.

Source: Hypertrophic Cardiomyopathy (HCM) 19. 2. 2024

Články časopisu Perceived attractiveness of Czech faces across 10 cultures: Associations with sexual shape dimorphism, averageness, fluctuating asymmetry, and eye color

Author of the article: Tomáš Kočnar, S. Adil Saribay, Karel Kleisner Source: PLOS One | 11/2019 1. 11. 2019

News Cenobamate −⁠ A Case Study from Slovak Real Practice

Cenobamate is indicated for adjunctive therapy of focal seizures with or without secondary generalization in adult patients who have not achieved sufficient results with previous treatment with at least 2 antiepileptics. This new anti-seizure medication with a dual mechanism of action thus brings another therapeutic option for patients refractory to treatment. At the November 34th Slovak-Czech Epileptology Congress in Bratislava, during a symposium titled “Is there hope for a quality life with epilepsy?” doc. MUDr. Eva Feketeová, PhD., from the Neurological Clinic LF UPJŠ and UNLP in Košice shared her first experiences with cenobamate in clinical practice.

Source: Epilepsy 23. 12. 2022