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News Final Analysis of the STASEY Study: How Did Emicizumab Fare in the Prophylaxis of Hemophilia A Patients with FVIII Inhibitors?

The July virtual congress of the International Society on Thrombosis and Haemostasis (ISTH) 2021 offered a variety of interesting topics. Among the poster presentations, data from the multicenter, single-arm, open-label phase III STASEY clinical trial, which evaluated the safety and tolerability of emicizumab prophylaxis in patients with hemophilia A and an FVIII inhibitor, were included. The results were presented on behalf of an international team of authors by Víctor Jiménez-Yuste from the University Hospital La Paz in Madrid.

Source: Rare Diseases in Hematology 21. 10. 2021

News If Suicides Were COVID-19... or Why We Still Overlook a Significant Cause of Premature Deaths?

More than a year since the start of the pandemic, the SARS-CoV-2 coronavirus has claimed 2.8 million lives globally, with 127 million recorded cases of COVID-19 (as of March 29, 2021). According to World Health Organization (WHO) data, there are 800,000 suicides annually, with suicide attempts being up to 20 times more frequent, totaling over 16 million. Given our current focus on physical health, are we overlooking the extent and importance of mental health issues in the population? This question has been raised by several experts from different countries in their submission to the February issue of The Journal of Clinical Psychiatry.

Source: Depression and Anxiety 30. 3. 2021

News New Natural Method for Prevention and Treatment of House Dust Mite Allergy

House dust mites are among the most common triggers of respiratory allergies. Until now, therapy has primarily focused on alleviating allergy symptoms. The aim of the new natural-based method is to eliminate the etiology of the issues, specifically the house dust mites themselves.

Source: Dust Mite Allergy 6. 10. 2020

News Can AI Help Accelerate the Development of Antibiotics for Gonorrhea and MRSA?

The overuse of antibiotics has helped bacteria become resistant to them. In the fight against antibiotic resistance, the involvement of artificial intelligence in the development of new drugs could prove beneficial. Using AI, experts from MIT examined more than 36 million possible compounds and evaluated their antimicrobial properties. The researchers also analyzed potential new compounds that had not yet been synthesized. The best candidate molecules discovered are structurally distinct from all existing antibiotics and appear to disrupt bacterial cell membranes through previously unobserved mechanisms.

Source: 2. 1. 2026

News Metamizole at a Glance and in Practice –⁠ Effective Non-Opioid Analgesic for All Ages

The regular webinar of the General Medicine Society of ČLS JEP this spring, besides addressing the current coronavirus situation, also focused on the issue and treatment of pain in its specialized section. Anesthesiologist MUDr. Jan Lejčko from the Pain Treatment Center at KARIM LF UK and FN Plzeň, Vice-President of the Society for the Study and Treatment of Pain ČLS JEP, concentrated on types of pain and principles and options of treatment, particularly using metamizole, in his lecture.

Source: Analgesia 15. 9. 2021

News Obstacle Called Vasospasm: Which Solution Is Most Effective in Microsurgery and How to Pharmacologically Assist It?

Turkish authors in their study focused on the use of metamizole in addressing vasospasm in microsurgery. Using an animal model, they sought to answer the question of how this drug compares to lidocaine and papaverine.

Source: Analgesia 27. 5. 2020

News Patient with Diabetes: When to Follow Up and When to Refer to a Specialist?

It is most often the general practitioner (GP) who first diagnoses diabetes. Whether during preventive check-ups, preoperative examinations, or based on the patient's clinical issues. After diagnosing diabetes, however, the GP faces a difficult decision: Will they continue to monitor and treat the patient themselves, or will they refer them to a diabetologist?

Source: Diabetes 6. 12. 2020

News How Could the Gut Microbiota Be Linked to a Higher Risk of Abdominal Aortic Aneurysm Progression?

A cohort study conducted in Europe and the United States demonstrated an association between elevated blood levels of trimethylamine N-oxide (TMAO)—a metabolite produced in the presence of the gut microbiota—and an increased risk of progression of abdominal aortic aneurysm (AAA). The findings, which may enable more precise identification of patients with rapidly expanding AAAs or those requiring surgical intervention, were published in JAMA Cardiology.

Source: proLékaře.cz 6. 2. 2026

News Can frequent nightmares be a harbinger of dementia?

Nightmares that occur regularly can be more than just an unpleasant experience—they represent a significant risk factor for cognitive impairment and the development of dementia. A British study led by neurologist Dr. Abidemi Otaiku has brought new insights into the connections between bad dreams and the decline in cognitive functions, including the onset of dementia.

Source: proLékaře.cz 22. 1. 2025

Články časopisu Ecosystem functioning in urban grasslands: The role of biodiversity, plant invasions and urbanization

Author of the article: Gabriela Onandia, Conrad Schittko, Masahiro Ryo, Maud Bernard-Verdier, Tina Heger, Jasmin Joshi, Ingo Kowarik, Arthur Gessler Source: PLOS One | 11/2019 1. 11. 2019

Články časopisu Analysis of genome-wide DNA arrays reveals the genomic population structure and diversity in autochthonous Greek goat breeds

Author of the article: S. Michailidou, G. Th. Tsangaris, A. Tzora, I. Skoufos, G. Banos, A. Argiriou, G. Arsenos Source: PLOS One | 12/2019 2. 12. 2019

News Etiology of Recurrent Reproductive Losses –⁠ Focus on Genetics

Repeated pregnancy losses pose a significant threat to a woman's physical and mental health. The etiology of up to half of these cases remains unexplained, and recurrent reproductive losses are considered a complex disease. We provide a brief overview of the current knowledge on their possible etiology and genetic correlations, both on the part of the mother and father.

Source: Genetics 4. 5. 2023

News When and why to consider the diagnosis of myasthenia gravis in neurological practice, and what treatment options do we currently have?

Myasthenia gravis (MG) is a clinically heterogeneous disease characterized by fluctuating muscle weakness and fatigability that worsens after physical exertion or mental stress. Accurate diagnosis is essential because treatment can lead to permanent remission and full functional capacity of the patient.

Source: Rare Diseases in Neurology 2. 5. 2023

Články časopisu Diet and Physical Activity for the Prevention of Noncommunicable Diseases in Low -⁠ and Middle-Income Countries: A Systematic Policy Review

Source: PLOS Medicine | 6/2013 11. 6. 2013

Články časopisu Integrating temperature-dependent life table data into Insect Life Cycle Model for predicting the potential distribution of Scapsipedus icipe Hugel & Tanga

Author of the article: Magara H. J. Otieno, Monica A. Ayieko, Saliou Niassy, Daisy Salifu, Azrag G. A. Abdelmutalab, Khamis M. Fathiya, Sevgan Subramanian, Komi K. M. Fiaboe, Nana Roos, Sunday Ekesi, Chrysantus M. Tanga Source: PLOS One | 9/2019 9. 9. 2019