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Články časopisu Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus

Author of the article: Xavier Grau-Bové, Eric Lucas, Dimitra Pipini, Emily Rippon, Arjèn E. van ‘t Hof, Edi Constant, Samuel Dadzie, Alexander Egyir-Yawson, John Essandoh, Joseph Chabi, Luc Djogbénou, Nicholas J. Harding, Alistair Miles, Dominic Kwiatkowski, Martin J. Donnelly, David Weetman, Source: PLOS Genetics | 1/2021 21. 1. 2021

News Impact of Tofacitinib on the Quality of Life of Patients with Ulcerative Colitis

Tofacitinib is an oral Janus kinase (JAK) inhibitor used in the treatment of certain rheumatic diseases and ulcerative colitis (UC). The work presented at this year's 18th congress of the European Crohn's and Colitis Organization (ECCO) in Copenhagen, Denmark, focused on its impact on the quality of life in terms of physical and mental functions in patients with UC.

Source: Intestinal Inflammations 7. 12. 2023

News Chairwoman of Revma Liga ČR: I Hope We Improve Our Approach and Treatment of Osteoporosis in the Czech Republic

Patients with inflammatory rheumatic diseases have a significantly increased risk of developing osteoporosis and related fractures. At the same time, this disease is considerably underestimated in the Czech Republic, and more attention is given to it only at the stage of osteoporotic fractures. To what extent does the patient organization Revma Liga ČR, which unites patients with rheumatic diseases, engage in this issue? We asked its chairwoman Edita Müllerová.

Source: Osteoporosis – Trends in Sequential Therapy 20. 12. 2023

News Efficacy and Safety of Levodopa/Entacapone/Carbidopa Combination in the Treatment of Advanced Parkinson's Disease –⁠ Prospective ELEGANCE Study

Therapy for advanced Parkinson's disease (PD) with a triple combination of levodopa/entacapone/carbidopa in the form of intestinal gel (LECIG) was first introduced to the Swedish market in 2018. The German team behind the ELEGANCE study aimed to gather available data and analyze the efficacy and safety of this modality in the long-term treatment of PD.

Source: Parkinson's Disease 22. 11. 2022

News How Does Cenobamate Compare with Third-Generation Anti-Seizure Medications in Terms of Cost-Effectiveness?

The main goal of epilepsy treatment is to achieve seizure freedom without unacceptable side effects of therapy. Despite the benefits of the latest generation of anti-seizure medications (ASMs), approximately 40% of patients suffer from drug-resistant epilepsy. The recently approved cenobamate brings new hope to patients. A Spanish pharmacoeconomic study aimed to compare the cost-effectiveness of cenobamate with selected third-generation ASMs as adjunctive therapy in patients with drug-resistant focal epilepsy.

Source: Epilepsy 8. 6. 2023

News Comparison of the Effect of Sonic and Manual Toothbrushes on Dental Plaque and Gingivitis Control

A clinical study on healthy volunteers with mild to moderate gingivitis compared the effectiveness of sonic and manual toothbrushes in terms of dental plaque and gingivitis occurrence. The results of the study showed that the sonic toothbrush outperformed the manual one in all observed parameters.

Source: Dental Care 16. 2. 2023

News Mental Health as an Overlooked Topic in Patients with Psoriasis

Psoriasis is an inflammatory, non-infectious disease primarily affecting the skin, and sometimes the nails, although in some patients, it manifests as psoriatic arthritis. To minimize the negative impact of these stigmatizing issues on patients' daily lives, not only optimal pharmacotherapy is crucial, but also the support of mental health.

Source: Psoriasis 4. 7. 2023

News Long-term Keto Diet May Damage Our Organs

Source: 5. 12. 2024

News Reduction of Inflammation in Vertebral Bodies and Posterolateral Structures of the Spine in Patients with Ankylosing Spondylitis Treated with Tofacitinib

A post hoc analysis of a phase II study with tofacitinib in patients with active ankylosing spondylitis (AS) evaluated the suppression of spinal inflammation using magnetic resonance imaging (MRI) based on the Canadian-Danish scoring system (CANDEN), which allows for the assessment of changes in posterolateral structures of the spine, characteristic of AS involvement.

Source: Arthritis 23. 11. 2023

News Genetic Testing in Clinical Practice –⁠ An Irreplaceable Tool in Prevention, Diagnosis and Treatment

Genetic testing has long ceased to be the privilege of clinical research. In practice, it is commonly used for screening, diagnosis, and prognosis determination in diseases with an evident genetic component, and subsequently for tailoring pharmacotherapy to the individual patient. The richest experience with genetic testing belongs to reproductive medicine and the field of prenatal diagnostics, as well as pediatrics associated with rare disease medicine and oncology. Today, the significance of testing is becoming apparent in internal medicine and psychiatry as well.

Source: Genetics 4. 4. 2023

Články časopisu Cardiorenal syndrome and gliflozins

Author of the article: Alena Šmahelová Source: Forum Diabetologicum | 3/2019 18. 12. 2019

News Seventy Years Since the First Czech Hemodialysis

It is not only the home of a legendary scientist said to have made a pact with the devil, but also the site of the Hemodialysis Center of the General University Hospital (VFN). At Prague’s Faust House, representatives of the Department of Nephrology of the First Faculty of Medicine, Charles University, and VFN in Prague commemorated a unique milestone —⁠ the performance of the first hemodialysis not only in former Czechoslovakia, but in the entire socialist bloc.

Source: proLékaře.cz 19. 1. 2026

News Can AI solve Europe’s healthcare workforce shortage?

According to BMJ Global Health, the global healthcare sector was short approximately 15 million healthcare workers in 2020. Although this number is expected to decline to 10 million by 2030, significant regional disparities remain. The consequences include delayed diagnostics, overburdened health systems, and a higher risk of complications due to inadequate care.

Source: proLékaře.cz 17. 10. 2025

News Evaluation of Treatment Response in CLL

The size of lymph nodes, liver, spleen, blood cell counts, systemic symptoms... Changes in these indicators provide clear information on whether the disease of chronic lymphocytic leukemia (CLL) has progressed, stabilized, or if the patient has achieved partial or complete remission after therapy. An even deeper insight into what has happened at the cellular level in the human body is provided by the evaluation of minimal residual disease (MRD). Why is it meaningful to search for the remaining leukemic cells? How to identify them, in what material, and when? And is the information about MRD truly useful for all types and lines of treatment? The answers to these questions, along with other current data and information on the topic, are brought by the following presentation.

Source: Chronic Lymphocytic Leukemia 9. 9. 2021

News Climbing Stairs Helps Prolong Life and Prevent Heart Disease

At the European Society of Cardiology (ESC) Congress on Preventive Cardiology, held in late April in Athens, Greece, a meta-analysis was presented that provides insight into how the heart, blood vessels, and the entire body benefit from choosing to take the stairs instead of the elevator or escalator.

Source: proLékaře.cz 17. 12. 2024