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News Prediction of Ischemic Stroke Risk in Patients with Rheumatoid Arthritis Using a Simplified Score

Ischemic strokes (iCMP) are a common cause of death or significant disability in developed countries. Patients with rheumatoid arthritis (RA) are affected by them even more frequently than the general population. A newly developed scoring system is capable of predicting the risk of iCMP in these patients.

Source: Arthritis 3. 12. 2020

News Analysis of the Benefits and Risks of Superabsorbent Dressings in the Treatment of Moderate to Highly Exuding Leg Ulcers

A study on the benefits and risks of superabsorbent dressings compared to standard dressings in the treatment of moderate to highly exuding leg ulcers was published last year in The International Journal of Lower Extremity Wounds.

Source: Wound Healing 22. 2. 2022

News What Results Does Bimekizumab Achieve in Patients with PsA After 3 Years of Treatment?

Fresh findings from the BE ACTIVE study were published this year in the journal Rheumatology, which evaluated the effects of long-term treatment of individuals with psoriatic arthritis (PsA) with bimekizumab in terms of patient-reported outcomes (PROs).

Source: Psoriasis 10. 8. 2023

News INFOGRAPHIC: How does liposomal ozonized oil work in treating eye infections?

Ozonized sunflower oil exhibits antimicrobial, anti-inflammatory, and healing properties, which is why it is added to eye drops intended for infection prevention. We bring you a clear schematic of the mechanism of action of liposomal ozonized oil.

Source: Treatment of Glaucoma 24. 3. 2023

News Continuation of Treatment with Tofacitinib in Rheumatoid Arthritis –⁠ Real-World Clinical Practice Data

The oral Janus kinase inhibitor tofacitinib has been extensively tested in patients with rheumatoid arthritis in numerous international randomized clinical trials. According to a recently published review summarizing retrospective, prospective, and observational studies from real-world clinical practice published in 2018–2020, the treatment duration with tofacitinib is comparable to that with biological disease-modifying drugs.

Source: Arthritis 29. 3. 2022

News Urgent Administration of Romiplostim in Life-Threatening Bleeding Associated with ITP

Recommendations for the care of acute, especially major bleeding in individuals with severe immune thrombocytopenia (ITP) are not entirely clear. Various methods (steroid boluses, intravenous immunoglobulins, platelet transfusions, etc.) can be used to quickly increase platelet count, but the response may not always be straightforward. Recently, reports have been published regarding the use of thrombopoietin receptor agonists (TPO-RAs) specifically aimed at rapidly increasing platelet count. The use of romiplostim in patients with ITP and intracranial hemorrhage is illustrated by the following case studies.

Source: Immune Thrombocytopenia 10. 8. 2022

News DPP-4 Inhibitors May Prevent SARS-CoV-2 Entry into Cells

Since the new type of coronavirus SARS-CoV-2 utilizes the DPP-4 receptor to enter human cells, DPP-4 inhibition by gliptins could represent a potential approach to pharmacological treatment of COVID-19 caused by this coronavirus.

Source: Diabetes 3. 8. 2020

News Safety Profile of Antiemetic Therapy in Patients Preparing for Hematopoietic Stem Cell Transplantation

An observational study conducted at a university clinic in Barcelona investigated the safety of the fixed combination of palonosetron and netupitant in patients preparing for hematopoietic stem cell transplantation.

Source: Antiemetic Therapy 15. 2. 2021

News Boy with Hemophilia A with Inhibitor −⁠ Case Study with Voting

Presented by: Assoc. Prof. MUDr. Jan Blatný, Ph.D., Department of Pediatric Hematology, University Hospital Brno

Source: Quality Life Even with Hemophilia 22. 4. 2020

News Height as an Independent Risk Factor for Varicose Veins

Authors of a study published in the journal Circulation analyzing data from nearly half a million people found another risk factor for the development of varicose veins –⁠ a person's height. They further assessed the possible causal role in the development of this pathology.

Source: Venous Insufficiency 1. 3. 2021

News Proposal of a New Treatment Sequence Algorithm for Heart Failure with Reduced Ejection Fraction

John McMurray and Milton Packer published a proposal for a new treatment sequence algorithm for patients with heart failure with reduced ejection fraction (HFrEF) based on current findings in the 2021 issue of Circulation. This procedure consists of three steps and, according to the authors, should be initiated in patients who have achieved euvolemia through the use of diuretics.

Source: Heart Failure 21. 2. 2022

News Is it beneficial to combine etanercept and methotrexate in the treatment of psoriatic arthritis?

The study presented below by Canadian, American, and British authors focused on comparing the efficacy of monotherapy with methotrexate, etanercept, and their combination in patients with psoriatic arthritis.

Source: Arthritis 28. 3. 2022

News Prim. Pavel Jindra: Biosimilars are an accessible and effective treatment modality in hematooncology

“Based on our experience so far, biosimilars represent an effective and safe alternative to original molecules. We are not afraid to use them anywhere in approved indications, and we are not afraid of switching either. Biosimilars are a significant step towards greater accessibility of hematooncological treatment for a wide group of patients,” states the head of the Hematology-Oncology Department of FN Plzeň, MUDr. Pavel Jindra, Ph.D., in our current interview.

Source: Oncological Treatment 24. 3. 2022

News First Effective Pharmacotherapy Modality for Negative Symptoms in Schizophrenia

Negative symptoms of schizophrenia significantly limit the quality of life and overall functioning of the patient. However, there have been no suitable medications to effectively suppress these symptoms until now. This is expected to change with the introduction of cariprazine into the antipsychotic armamentarium, as suggested by promising results from an analysis published last year in the journal European Psychiatry.

Source: Schizophrenia and Antipsychotics 21. 2. 2020

News Impact of Body Mass Index on Survival and Treatment Outcomes of Metastatic Colorectal Cancer

A pooled analysis of 25 studies with patients in the first line of treatment for metastatic colorectal cancer (mCRC) evaluated the prognostic and predictive significance of body mass index (BMI). Until its publication in 2015, only the adverse impact of low and high BMI on outcomes in patients with early stages of colorectal cancer was known.

Source: Colorectal Cancer 17. 5. 2020